PI 3-kinase p110 delta Inhibitors
Phosphoinositide 3-kinase p110δ (PI3Kδ) inhibitors form a distinct chemical class meticulously crafted to selectively target and impede the activity of the p110δ isoform within the phosphoinositide 3-kinase (PI3K) signaling pathway. This signaling cascade serves as a linchpin in cellular communication, functioning as a conduit for transmitting signals from cell surface receptors to intracellular targets. The PI3K pathway's influence extends across diverse cellular processes, intricately regulating phenomena such as cell growth, survival, and metabolism.
The mechanism of action of PI3Kδ inhibitors hinges on their precision targeting of the p110δ isoform within the PI3K enzyme. These inhibitors are designed to disrupt the catalytic activity of PI3Kδ, impeding its ability to phosphorylate phosphoinositide substrates. This targeted interference has the ability to modulate the PI3K signaling pathway, exerting influence over downstream signaling cascades that orchestrate various cellular responses. Ongoing research dedicated to PI3Kδ inhibitors is committed to unraveling the intricate mechanisms that govern their actions, emphasizing a nuanced understanding of PI3K signaling and its multifaceted role in cellular physiology. The exploration of PI3Kδ inhibitors contributes substantively to the scientific understanding of the complex regulatory mechanisms governing cellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DNA-PK Inhibitor IV | sc-221562 sc-221562A sc-221562B | 1 mg 100 mg 20 mg | $30.00 $200.00 $50.00 | |||
DNA-PK Inhibitor IV selectively targets the p110 delta isoform of PI3-kinase, showcasing a unique mechanism of action through its interaction with the enzyme's regulatory domains. This compound influences the conformational dynamics of the kinase, leading to altered substrate affinity and reaction kinetics. Its distinct binding characteristics facilitate the modulation of signaling cascades, thereby impacting cellular responses and metabolic flux in a nuanced manner. | ||||||
DNA-PK Inhibitor III | 404009-40-1 | sc-203928 | 1 mg | $194.00 | ||
DNA-PK Inhibitor III exhibits selective inhibition of the p110 delta isoform of PI3-kinase, characterized by its ability to disrupt key protein-protein interactions within the kinase complex. This compound alters the phosphorylation state of downstream targets, influencing critical signaling pathways. Its unique structural features enable it to stabilize specific conformations of the enzyme, thereby modulating enzymatic activity and cellular signaling dynamics with precision. | ||||||
PI 3-Kγ Inhibitor | 648450-29-7 | sc-203191 | 5 mg | $76.00 | ||
PI 3-Kγ Inhibitor selectively targets the p110 delta isoform of PI3-kinase, demonstrating a unique ability to interfere with lipid binding sites, which alters membrane localization and activity. This compound exhibits distinct reaction kinetics, favoring rapid dissociation from the enzyme, which impacts downstream signaling cascades. Its specific molecular interactions facilitate the modulation of cellular responses, highlighting its role in fine-tuning kinase activity and pathway regulation. | ||||||
AS-605240 | 648450-29-7 | sc-221272 sc-221272A | 1 mg 5 mg | $23.00 $80.00 | 1 | |
AS-605240 is a selective inhibitor of the p110 delta isoform of PI3-kinase, characterized by its unique ability to disrupt protein-protein interactions within signaling complexes. This compound exhibits a high affinity for the enzyme's active site, leading to altered phosphorylation patterns and downstream effects on cellular metabolism. Its distinct binding dynamics influence the stability of lipid rafts, thereby modulating cellular signaling pathways and influencing cellular homeostasis. | ||||||
PIK-294 | 900185-02-6 | sc-364586 sc-364586A | 5 mg 50 mg | $309.00 $1764.00 | ||
PIK-294 is a selective inhibitor targeting the p110 delta isoform of PI3-kinase, notable for its capacity to modulate lipid metabolism through specific interactions with the enzyme's regulatory subunits. This compound alters the kinetics of substrate phosphorylation, resulting in a unique profile of downstream signaling events. Its binding affinity impacts the conformation of the enzyme, influencing the assembly of signaling complexes and affecting cellular responses to growth factors. | ||||||
LY 294002, 4′-NH2 | 942289-87-4 | sc-203121 sc-203121A | 5 mg 50 mg | $357.00 $2040.00 | 1 | |
LY 294002, 4′-NH2 is a selective inhibitor of the p110 delta isoform of PI3-kinase, characterized by its ability to disrupt the enzyme's catalytic activity. This compound engages in specific hydrogen bonding interactions with key residues, altering the enzyme's active site conformation. By modulating the phosphorylation dynamics of various substrates, it influences critical signaling pathways, thereby affecting cellular processes such as metabolism and survival. Its unique structural features contribute to its specificity and efficacy in targeting PI3-kinase activity. | ||||||
PIK-293 | 900185-01-5 | sc-364585 sc-364585A | 5 mg 50 mg | $370.00 $1950.00 | ||
PIK-293 is a selective inhibitor of the p110 delta isoform of PI3-kinase, known for its unique ability to stabilize the inactive conformation of the enzyme. This compound exhibits distinct molecular interactions, including hydrophobic contacts and van der Waals forces, which effectively hinder substrate binding. By altering the enzyme's kinetic parameters, PIK-293 modulates downstream signaling cascades, impacting cellular functions such as growth and differentiation. Its structural characteristics enhance its specificity for p110 delta, making it a valuable tool for studying PI3-kinase-related pathways. | ||||||
TG100-115 | 677297-51-7 | sc-364634 sc-364634A | 5 mg 100 mg | $250.00 $1873.00 | 1 | |
TG100-115 is a selective inhibitor targeting the p110 delta isoform of PI3-kinase, characterized by its unique ability to disrupt the enzyme's active site through specific hydrogen bonding and steric hindrance. This compound alters the enzyme's reaction kinetics, leading to a significant reduction in phosphoinositide production. Its distinct structural features promote high affinity for p110 delta, facilitating detailed investigations into its regulatory roles in cellular signaling networks. | ||||||
BAG 956 | 853910-02-8 | sc-291923 sc-291923A | 10 mg 50 mg | $215.00 $906.00 | ||
BAG 956 is a selective inhibitor of the p110 delta isoform of PI3-kinase, distinguished by its capacity to modulate enzyme activity through unique allosteric interactions. This compound exhibits a remarkable ability to stabilize inactive conformations of the enzyme, thereby influencing downstream signaling pathways. Its kinetic profile reveals a nuanced impact on substrate binding, allowing for precise exploration of p110 delta's role in cellular processes and metabolic regulation. | ||||||
XL-147 derivative 1 | 1349796-36-6 | sc-364660 sc-364660A | 5 mg 50 mg | $189.00 $1725.00 | ||
XL-147 derivative 1 is a potent inhibitor of the p110 delta isoform of PI3-kinase, characterized by its ability to disrupt specific protein-protein interactions within the kinase domain. This compound exhibits unique binding kinetics, favoring a transition to a less active state, which alters the phosphorylation dynamics of key substrates. Its selective engagement with the enzyme's active site provides insights into the regulatory mechanisms governing cellular signaling pathways, enhancing our understanding of metabolic control. | ||||||