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PIK-294 displays selectivity with respect to the inhibition of PI3K isoforms p110β, p110δ, and p110γ. PIK-294 exhibits low sensitivity to p110α with an IC50 value of 10 μM. The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIK-294, 5 mg | sc-364586 | 5 mg | $309.00 | |||
PIK-294, 50 mg | sc-364586A | 50 mg | $1764.00 |