PIK-294 CAS: 900185-02-6
MF: C28H23N7O2
MW: 489.53
A selective PI3K inhibitor.

PIK-294 (CAS 900185-02-6)

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Application: PIK-294 is a selective PI3K inhibitor
CAS Number: 900185-02-6
Molecular Weight: 489.53
Molecular Formula: C28H23N7O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PIK-294 displays selectivity with respect to the inhibition of PI3K isoforms p110β, p110δ, and p110γ, however it is most selective for PI3Kδ (IC 50 = 490, 10, and 160 nM, respectively). PIK-294 exhibits low sensitivity to p110Yalpha; with an IC50 value of 10 μM. The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity.

Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
24905149
SMILES :
CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=C(C(=N4)C6=CC(=CC=C6)O)C(=NC=N5)N

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Certificate of Analysis

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