PhLP Activators
Phosducin-like protein (PhLP) is a cytosolic protein that plays a critical role in the regulation of G-protein signaling within cells. It is part of a broader family of proteins that interact with the beta and gamma subunits of heterotrimeric G proteins, which are pivotal in conveying signals from G protein-coupled receptors (GPCRs) to intracellular effector pathways. PhLP acts as a co-chaperone, assisting in the folding and assembly of G-protein subunits by forming complexes with the cytosolic chaperonin CCT (chaperonin containing TCP-1).
The function of PhLP is not limited to the assembly of G-protein subunits; it also participates in the regulation of their signaling. By binding to the Gβγ dimer, PhLP can influence the availability of Gβγ for signaling, thereby modulating the intensity and duration of the signal transduction. This interaction is crucial for maintaining the balance of G-protein signaling, which is essential for numerous physiological processes, including vision, taste, and olfactory perception, as well as the regulation of mood, immune responses, and cardiovascular function.Dysregulation of PhLP expression or function can have significant implications for cellular signaling and has been associated with various diseases. For instance, aberrant G-protein signaling is a feature of certain cancers, cardiovascular diseases, and neurological disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
May increase cAMP levels, potentially affecting signaling pathways that regulate PhLP expression. | ||||||
Heat Shock Protein Inhibitor I | 218924-25-5 | sc-221709 | 5 mg | $97.00 | 5 | |
Heat shock induces stress proteins and could upregulate PhLP as part of the cellular stress response. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
As an Hsp90 inhibitor, it may disrupt protein folding and lead to increased expression of co-chaperones like PhLP. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that could lead to the accumulation of misfolded proteins, potentially increasing PhLP expression for protein quality control. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress and could upregulate PhLP as part of the unfolded protein response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Another inducer of ER stress, which may enhance the expression of molecular chaperones including PhLP. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Induces oxidative stress and may increase the expression of various stress response proteins, including PhLP. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known to modulate multiple cellular pathways, it could affect the expression of proteins involved in G-protein signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
May influence various signaling pathways and could potentially increase the expression of PhLP. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As an HDAC inhibitor, it can alter gene expression, potentially affecting PhLP levels. | ||||||