PHF23 Activators
PHF23 activators are a class of chemical compounds specifically designed to upregulate the activity of the plant homeodomain finger protein 23 (PHF23). PHF23 is part of a larger family of PHD finger proteins that typically function as readers of epigenetic marks, particularly those on histones, thus impacting gene expression indirectly through chromatin modification and remodeling. Activators targeting PHF23 aim to enhance its ability to recognize and bind to specific histone modifications, which in turn could modulate the transcriptional landscape of the cell. This modulation could occur through the stabilization of PHF23 in a conformation that favors active engagement with chromatin or through allosteric effects that increase its binding affinity for epigenetic marks. These activators could also potentially enhance interaction with other proteins in the chromatin remodeling complexes, further influencing gene expression patterns.
The discovery and characterization of PHF23 activators involve a deep understanding of the structure and function of the PHD finger domain, as well as the specific epigenetic marks recognized by PHF23. The development of these compounds also requires a careful examination of the selectivity, ensuring that the activators do not cross-react with other PHD finger proteins or disrupt the normal function of the epigenetic machinery. By crafting activator molecules with high specificity and potency for PHF23, researchers can use these tools to investigate the biological role of PHF23 in chromatin dynamics and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
A diacylglycerol analog that activates protein kinase C (PKC), potentially leading to the phosphorylation of transcription factors that could enhance PHF23 expression. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
A histone acetyltransferase activator that may increase the acetylation of histones around the PHF23 gene, enhancing its transcription. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
A metal ion that can act as a cofactor for transcription factors and may directly enhance the DNA binding and transcriptional activity of proteins that regulate PHF23 expression. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Hypoxia-mimetic agent that stabilizes HIF-1alpha, potentially leading to the transcriptional activation of genes including PHF23. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
An adenosine kinase inhibitor, which may increase intracellular adenosine, leading to the activation of the A2A receptor and subsequent upregulation of genes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA and could lead to the phosphorylation of CREB, enhancing transcription of target genes such as PHF23. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that can increase cAMP levels in cells, leading to activation of PKA and potential upregulation of PHF23 through CREB activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
An inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium and potentially enhancing activation of calcium-dependent transcription factors affecting PHF23 expression. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that can increase intracellular calcium concentrations, potentially enhancing the activity of calcium-sensitive signaling pathways that upregulate PHF23. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
A sphingosine-1-phosphate receptor modulator, which may indirectly upregulate gene expression including PHF23 by altering intracellular signaling pathways. | ||||||