PGRP-Iα Inhibitors
Peptidoglycan recognition protein (PGRP) inhibitors, specifically PGRP-Iα inhibitors, represent a class of chemicals that target the activity of PGRP-Iα, a protein involved in the immune response. PGRPs are part of a family of pattern recognition receptors (PRRs) that recognize peptidoglycan, a major component of bacterial cell walls, and play a role in modulating immune pathways, particularly innate immune responses. PGRP-Iα, as one of these proteins, is critical in sensing bacterial infections by identifying peptidoglycans from both Gram-positive and Gram-negative bacteria. By inhibiting PGRP-Iα, these compounds interfere with the protein's ability to bind or degrade peptidoglycan, thereby affecting downstream molecular interactions that regulate immune responses. This mechanism of action makes these inhibitors valuable for studying PGRP-Iα's structure, function, and broader role in immune signaling.
PGRP-Iα inhibitors can be useful tools in elucidating the molecular mechanisms that govern the interactions between host immune cells and invading pathogens. Since PGRPs are highly conserved across species, PGRP-Iα inhibitors also contribute to comparative studies between different organisms, helping to clarify how innate immunity evolved and operates in various biological systems. These inhibitors typically target the binding sites or catalytic domains of PGRP-Iα, providing insight into structural biology and protein-protein interactions. Additionally, research involving these inhibitors helps to uncover how PGRP-Iα-mediated signaling pathways are integrated with other immune system components, making them essential for basic research in microbiology, immunology, and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone can suppress the inflammatory response by downregulating NF-κB signaling, which in turn can decrease the transcription of PGRP-Iα, a gene typically upregulated during immune challenges. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may interfere with the NF-κB pathway and subsequently reduce the transcriptional activity of genes involved in the immune response, including the gene encoding PGRP-Iα. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
This polyphenolic compound has been shown to inhibit the activation of NF-κB, which could lead to a decrease in PGRP-Iα gene transcription as part of its anti-inflammatory properties. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, through its antioxidant properties, may downregulate the expression of immune-related genes such as PGRP-Iα by attenuating the activity of transcription factors like NF-κB and AP-1. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin can irreversibly inhibit cyclooxygenase enzymes, leading to a decrease in pro-inflammatory mediators and potentially reducing the transcription of PGRP-Iα. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can bind to its nuclear receptors and repress genes involved in inflammation; this could include a reduction in PGRP-Iα expression as part of its role in immune system modulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane might decrease PGRP-Iα expression by suppressing the NF-κB pathway and activating Nrf2, leading to a downregulation of inflammatory genes. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
By interfering with lysosomal activity and potentially altering TLR signaling, hydroxychloroquine can contribute to the decreased expression of TLR-responsive genes, including PGRP-Iα. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin can downregulate pro-inflammatory cytokine production, which may result in a decrease in PGRP-Iα gene expression as it is often co-expressed with these cytokines. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
As an NSAID, indomethacin may inhibit the COX pathway, leading to a reduction in inflammatory mediators and a consequent decrease in PGRP-Iα expression. | ||||||