PGRP-Iα Antibody (187C434): sc-52946

PGRP-Iα Antibody (187C434) is a mouse monoclonal IgG1 antibody that detects the PGRP-I alpha protein of human origin by western blotting (WB), immunofluorescence (IF), and flow cytometry (FCM). Anti-PGRP-I alpha antibody (187C434) is available as the non-conjugated format. Peptidoglycan recognition proteins (PGRPs) play a crucial role in the immune response by recognizing peptidoglycan, a key component of bacterial cell walls. In mammals, PGRP-Iα functions as an antibacterial protein, contributing to the innate immune defense by binding to and recognizing Gram-positive bacteria. This interaction is vital for the activation of immune pathways that lead to the clearance of bacterial infections. PGRP-Iα, along with PGRP-Iβ, is expressed in various tissues, including the esophagus, tonsils, and thymus, where these proteins help to maintain mucosal immunity. Both proteins are transmembrane proteins, with PGRP-Iα consisting of 341 amino acids, and contain highly conserved C-terminal PGRP domains that facilitate interaction with peptidoglycan. PGRP-Iα′s ability to bind to bacterial components underscores its significance in the immune system, making PGRP-Iα a valuable target for research in understanding host-pathogen interactions and developing therapeutic strategies.

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PGRP-Iα Antibody (187C434) References:

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