PGD2 synthase Activators
Prostaglandin D2 synthase (PGD2 synthase) is an enzyme that plays a crucial role in the synthesis of prostaglandin D2 (PGD2), a bioactive lipid mediator found in arachidonic acid metabolism. PGD2 is involved in various physiological processes, including inflammation, allergic responses, and regulation of sleep-wake cycles. PGD2 synthase catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2, which serves as a precursor for the synthesis of other prostanoids. The enzyme is widely expressed in various tissues, including mast cells, macrophages, and brain tissues, reflecting its diverse roles in different physiological systems.
The activation of PGD2 synthase is regulated at multiple levels. One mechanism involves post-translational modifications such as phosphorylation, which can modulate the enzyme's activity. Additionally, the expression of PGD2 synthase is regulated by various signaling pathways and transcription factors. For instance, inflammatory mediators such as cytokines and growth factors can stimulate the expression of PGD2 synthase by activating specific transcription factors. Moreover, cellular stressors and environmental stimuli may also influence the activity of PGD2 synthase through intricate signaling cascades. Overall, the activation of PGD2 synthase is tightly regulated to ensure proper control of PGD2 synthesis in response to physiological and pathological stimuli, highlighting its significance in maintaining homeostasis and orchestrating cellular responses.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Butaprost | 69685-22-9 | sc-221387 sc-221387A | 500 µg 1 mg | $124.00 $237.00 | 1 | |
Butaprost is a selective agonist for the prostaglandin D2 (PGD2) receptor DP2 (also known as CRTH2). By binding to and activating DP2, Butaprost directly stimulates the downstream signaling pathways associated with PGD2 receptor activation. | ||||||
BW A868C | 118675-50-6 | sc-204660 sc-204660A | 1 mg 10 mg | $143.00 $1142.00 | ||
BW A868C is a potent and selective agonist for the prostaglandin D2 (PGD2) receptor DP2 (also known as CRTH2). As a DP2 agonist, BW A868C directly binds to and activates the receptor, initiating the downstream signaling cascades associated with PGD2 receptor activation. | ||||||
15(R)-15-methyl Prostaglandin D2 | 210978-26-0 | sc-223169 sc-223169A | 500 µg 1 mg | $71.00 $122.00 | ||
15(R)-15-methyl PGD2 is an isomer of prostaglandin D2 (PGD2) and acts as a selective agonist for the PGD2 receptor DP1. By binding to DP1, this compound directly activates the receptor, initiating the downstream signaling pathways associated with PGD2 receptor activation. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton is a 5-lipoxygenase inhibitor that indirectly modulates PGD2 synthesis. By inhibiting 5-lipoxygenase, Zileuton interferes with the conversion of arachidonic acid to leukotrienes, shifting the balance toward the production of PGD2. | ||||||
Deoxycholic acid | 83-44-3 | sc-214865 sc-214865A sc-214865B | 5 g 25 g 1 kg | $36.00 $66.00 $923.00 | 4 | |
Deoxycholic acid is a bile acid that has been reported to stimulate PGD2 synthesis in certain contexts. While the exact mechanism is not fully elucidated, studies suggest that deoxycholic acid may influence the arachidonic acid pathway, leading to increased PGD2 production. | ||||||
PGD2 (Prostaglandin D2) | 41598-07-6 | sc-201221 sc-201221A | 1 mg 10 mg | $94.00 $572.00 | 4 | |
Prostaglandin D2 (PGD2) itself can act as an autocrine or paracrine activator of its receptors DP1 and DP2. By binding to these receptors, PGD2 directly initiates the downstream signaling pathways associated with PGD2 receptor activation. This autocrine or paracrine activation results in a feedback loop that regulates PGD2 levels and modulates its biological effects. | ||||||
(+)-Fluprostenol | 54276-17-4 | sc-205326 sc-205326A | 1 mg 10 mg | $66.00 $398.00 | ||
Fluprostenol is a prostaglandin analog that has been reported to stimulate PGD2 synthesis. Although the exact mechanism is not fully elucidated, studies suggest that Fluprostenol may influence the arachidonic acid pathway, leading to increased PGD2 production. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid, a polyunsaturated fatty acid, serves as a substrate for the synthesis of various eicosanoids, including prostaglandin D2 (PGD2). Its availability and release from membrane phospholipids contribute to the pool of arachidonic acid available for enzymatic conversion by cyclooxygenases. | ||||||