Molecular structure of PGD2 (Prostaglandin D2), CAS Number: 41598-07-6
PGD2 (Prostaglandin D2) (CAS 41598-07-6)
See product citations (4)
Alternate Names:
9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Application:
PGD2 (Prostaglandin D2) is a major regulator shown to bind DP and CRTH2 receptors that inhibits platelet aggregation
CAS Number:
41598-07-6
Purity:
≥98%
Molecular Weight:
352.47
Molecular Formula:
C20H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PGD2(Prostaglandin D2) is a bioactive lipid compound that is researched in the context of inflammatory and allergic responses. It is a product of the cyclooxygenase pathway, synthesized primarily by mast cells. In research, PGD2 is studied for its involvement in the modulation of inflammation, where it interacts with specific receptors, namely DP1 and DP2/CRTH2, to exert its biological effects. Research on PGD2 also encompasses its role in sleep-wake regulation, as it is a major prostaglandin produced in the brain that can influence sleep patterns. Additionally, studies investigate the contribution of PGD2 to the pathophysiology of conditions such as asthma and allergic rhinitis, as well as its potential involvement in the resolution of inflammation.
PGD2 (Prostaglandin D2) (CAS 41598-07-6) References
- On the role of PGD2 metabolites as markers of mast cell activation in asthma. | O'Sullivan, S. 1999. Acta Physiol Scand Suppl. 644: 1-74. PMID: 10352758
- Correlation of increased concentration of ovine endometrial cyclooxygenase 2 with the increase in PGE2 and PGD2 in the late luteal phase. | Charpigny, G., et al. 1999. J Reprod Fertil. 117: 315-24. PMID: 10690199
- PGD2 and its mimetic ZK 110.841 are potent inhibitors of receptor-mediated activation of human neutrophils. | Ney, P. and Schrör, K. 1991. Eicosanoids. 4: 21-8. PMID: 1647806
- Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. | Oguma, T., et al. 2008. Allergol Int. 57: 307-12. PMID: 18946232
- Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites. | Higashi, N., et al. 2012. Allergol Int. 61: 393-403. PMID: 22627848
- PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. | Werder, RB., et al. 2018. Sci Transl Med. 10: PMID: 29743346
- Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | Onoe, H., et al. 1988. Proc Natl Acad Sci U S A. 85: 4082-6. PMID: 3163802
- Prostaglandin D2 and its analog, 11d-11m-PGD2, added during the differentiation phase contribute to adipogenic program inhibition in 3T3-L1 cells. | Nartey, MNN., et al. 2022. Biosci Biotechnol Biochem. 86: 628-634. PMID: 35266506
- Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. | Xiong, Z., et al. 2022. Immunity. 55: 686-700.e7. PMID: 35320705
- Prostaglandin D2 inhibits the aggregation of human platelets. | Smith, JB., et al. 1974. Thromb Res. 5: 291-9. PMID: 4439372
- Regional distribution of prostaglandins D2, E2, and F2 alpha and related enzymes in postmortem human brain. | Ogorochi, T., et al. 1984. J Neurochem. 43: 71-82. PMID: 6427411
- Prostaglandin D2 inhibits the proliferation of human malignant tumor cells. | Sakai, T., et al. 1984. Prostaglandins. 27: 17-26. PMID: 6584941
- Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. | Lewis, RA., et al. 1982. J Immunol. 129: 1627-31. PMID: 6809826
- Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. | Kikuchi, Y., et al. 1994. Cancer Metastasis Rev. 13: 309-15. PMID: 7712593
Activator of:
c-Fms/CSF-1R, CD203c, COX1, DP, DP-2, DP2, DP2_CRTH2, GPR-44, Mast Cell Protease 1, Mast Cell Protease 7, PGD2 synthase, and Skp2 p45.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGD2 (Prostaglandin D2), 1 mg | sc-201221 | 1 mg | $94.00 | |||
PGD2 (Prostaglandin D2), 10 mg | sc-201221A | 10 mg | $572.00 |