Molecular structure of (+)-Fluprostenol, CAS Number: 54276-17-4
(+)-Fluprostenol (CAS 54276-17-4)
Alternate Names:
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid; [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
Application:
(+)-Fluprostenol is a metabolically stable PGF2αR agonist
CAS Number:
54276-17-4
Purity:
>90%
Molecular Weight:
458.47
Molecular Formula:
C23H29F3O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
(+)-Fluprostenol is the optically active enantiomer of fluprostenol (sc-201336). It is a metabolically stable analog of PGF2α and a potent FP prostanoid receptor (PGF2αR) agonist. The expected potency of (+)-fluprostenol is twice that of (±)-fluprostenol for PGF2α binding to human and rat FP receptors. (+)-Fluprostenol is an effective inhibitor of rat adipose precursor differentiation in primary cultures.
(+)-Fluprostenol (CAS 54276-17-4) References
- NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. | Katsuyama, M., et al. 2002. J Biol Chem. 277: 13438-42. PMID: 11832489
- Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS. | McCue, BA., et al. 2002. J Pharm Biomed Anal. 28: 199-208. PMID: 11929662
- Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved. | Józefowski, S., et al. 2003. Int Immunopharmacol. 3: 865-78. PMID: 12781703
- Potent luteolytic agents related to prostaglandin F2alpha. | Dukes, M., et al. 1974. Nature. 250: 330-1. PMID: 4853720
- Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. | Lake, S., et al. 1994. FEBS Lett. 355: 317-25. PMID: 7988697
- Cloning and expression of a cDNA for the human prostanoid FP receptor. | Abramovitz, M., et al. 1994. J Biol Chem. 269: 2632-6. PMID: 8300593
- Prostaglandin F2alpha receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. | Serrero, G. and Lepak, NM. 1997. Biochem Biophys Res Commun. 233: 200-2. PMID: 9144422
Activator of:
PGD2 synthase, and PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Fluprostenol, 1 mg | sc-205326 | 1 mg | $66.00 | |||
(+)-Fluprostenol, 10 mg | sc-205326A | 10 mg | $398.00 |