Molecular structure of Butaprost, CAS Number: 69685-22-9
Butaprost (CAS 69685-22-9)
See product citations (1)
Application:
Butaprost is a structural analog of PGE2 and a selective agonist of EP2 subtype receptors
CAS Number:
69685-22-9
Purity:
>98%
Molecular Weight:
408.6
Molecular Formula:
C24H40O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle. This compound binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors. The EC50 for the stimulation of cAMP by butaprost in COS cells transfected with the human EP2 receptor is about 5 muM, while the EC50 for PGE2 in this assay is about 43 nM.
Butaprost (CAS 69685-22-9) References
- An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women. | Duckworth, N., et al. 2002. J Endocrinol. 172: 263-9. PMID: 11834444
- Comparison of prostaglandin F2alpha, bimatoprost (prostamide), and butaprost (EP2 agonist) on Cyr61 and connective tissue growth factor gene expression. | Liang, Y., et al. 2003. J Biol Chem. 278: 27267-77. PMID: 12724323
- Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription. | Liang, Y., et al. 2004. Br J Pharmacol. 142: 737-48. PMID: 15159280
- The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey. | Nilsson, SF., et al. 2006. Invest Ophthalmol Vis Sci. 47: 4042-9. PMID: 16936121
- Trigeminal nociceptors express prostaglandin receptors. | Patwardhan, AM., et al. 2008. J Dent Res. 87: 262-6. PMID: 18296611
- Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia. | Osborne, NN., et al. 2009. Invest Ophthalmol Vis Sci. 50: 3238-48. PMID: 19264896
- The localization of PGE2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost. | Andrade da Costa, BL., et al. 2009. Neurochem Int. 55: 199-207. PMID: 19524109
- EP2 Receptor Signaling Regulates Microglia Death. | Fu, Y., et al. 2015. Mol Pharmacol. 88: 161-70. PMID: 25715797
- Anti-scarring effects of butaprost on human subconjunctival Tenon's fibroblasts. | Shin, JH., et al. 2017. Int J Ophthalmol. 10: 1028-1033. PMID: 28730102
- Prostaglandin E2/EP2 receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes. | Wang, M., et al. 2019. Diabetologia. 62: 335-348. PMID: 30411254
- Involvement of EP2 and EP4 Receptors in Eosinophilic Esophagitis: A Pilot Study. | Durchschein, F., et al. 2019. Dig Dis Sci. 64: 2806-2814. PMID: 30989466
- Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. | Jensen, MS., et al. 2019. Acta Physiol (Oxf). 227: e13291. PMID: 31054202
- Celecoxib induces apoptosis through Akt inhibition in 5-fluorouracil-resistant gastric cancer cells. | Choi, SM., et al. 2021. Toxicol Res. 37: 25-33. PMID: 33489855
- Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent blindness. | Sharif, NA. 2023. Exp Eye Res. 232: 109444. PMID: 36958427
Activator of:
BRAK, EP1, EP3, EP4, FBL17, FOXP1, GPR-44, MCP-5, PGD2 synthase, PGE synthase, and TSSC3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butaprost, 500 µg | sc-221387 | 500 µg | $126.00 | |||
Butaprost, 1 mg | sc-221387A | 1 mg | $242.00 |