PFKP Activators
The chemical class of PFKP activators comprises a diverse range of compounds that indirectly influence the activity of PFKP through their effects on metabolic pathways, insulin signaling, and cellular energy balance. These activators function by modulating the biochemical and cellular processes that converge on glycolysis, where PFKP plays a critical role. The primary mechanism through which these compounds exert their effects is through the alteration of glucose utilization, insulin sensitivity, and energy metabolism, impacting the function of glycolytic enzymes like PFKP.
Compounds such as insulin, metformin, and epinephrine work by regulating the cellular uptake and utilization of glucose, which in turn can influence the activity of glycolytic enzymes including PFKP. Insulin, for instance, enhances glycolysis by upregulating glycolytic enzymes, thereby potentially increasing PFKP activity. Metformin activates AMPK, leading to changes in glucose metabolism and energy balance, which can indirectly affect the function of PFKP in glycolysis. In addition to these, compounds like resveratrol, curcumin, and alpha-lipoic acid modulate various cellular metabolic pathways. By influencing these pathways, these compounds can indirectly affect the glycolytic flux and, consequently, PFKP activity. Furthermore, pharmaceutical agents such as pioglitazone and fenofibrate, which modulate insulin sensitivity and lipid metabolism, respectively, can also influence PFKP activity indirectly through their impact on overall metabolic balance and glucose metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can enhance glycolysis by upregulating key glycolytic enzymes including PFKP. It does so by activating the PI3K/AKT pathway, which leads to increased glucose uptake and utilization, indirectly influencing PFKP activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK, which can lead to the alteration of glycolytic flux. This activation may indirectly influence PFKP by altering cellular energy balance and the regulation of glucose metabolism. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, through its action on adrenergic receptors, can influence metabolic pathways and indirectly affect PFKP activity by modulating energy demand and glycolytic flux in cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, by influencing cellular energy metabolism and possibly increasing AMP levels, can indirectly affect PFKP activity through alterations in cellular energy states. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine can modulate glucose metabolism and may indirectly influence PFKP activity through its effects on metabolic pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, by modulating metabolic pathways and enhancing insulin sensitivity, can indirectly affect PFKP activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple cellular pathways including glucose metabolism, potentially indirectly influencing PFKP activity. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-Lipoic Acid affects cellular metabolism and could indirectly influence PFKP activity through its effects on energy metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-γ agonist, enhances insulin sensitivity and could indirectly influence PFKP activity through improved glycolytic flux due to enhanced glucose utilization. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate, by activating PPAR-α, can influence lipid metabolism and indirectly affect PFKP activity through alterations in cellular energy balance and glucose metabolism. | ||||||