Peroxin 1 Activators
Peroxin 1 activators are a class of chemicals that directly or indirectly enhance the functional activity of Peroxin 1. Peroxin 1 is a central player in peroxisome assembly, and its activation can be influenced by various signaling pathways. For instance, Phorbol 12-myristate 13-acetate (PMA) and Diacylglycerol (DAG) activate Protein Kinase C (PKC), which stimulates the translocation of Peroxin 1 to peroxisomes, where it functions in peroxisome assembly. Similarly, Forskolin, by activating adenylate cyclase, leads to elevated cyclic AMP (cAMP) levels, in turn activating PKA, which can phosphorylate Peroxin 1 and enhance its functional activity in peroxisome assembly.
Epidermal Growth Factor (EGF) activates the EGF receptor, leading to the activation of the MAPK/ERK pathway, which can enhance the translocation of Peroxin 1 to peroxisomes. Likewise, Lysophosphatidic Acid (LPA) activates G protein-coupled receptors, leading to PKCactivation and the subsequent stimulation of Peroxin 1's translocation to peroxisomes, thereby enhancing its role in peroxisome assembly. On the other hand, Ionomycin enhances intracellular calcium concentrations, and the elevated calcium can activate PKC, which in turn enhances Peroxin 1's functional activity. Calmodulin, a calcium-binding messenger protein, interacts with various protein kinases that can phosphorylate Peroxin 1, enhancing its functional activity in peroxisome assembly. In contrast, Okadaic acid, by inhibiting protein phosphatases PP1 and PP2A, can sustain the phosphorylation state and thus the activation of Peroxin 1. Phosphatidylserine, a phospholipid component of the cell membrane, can activate PKC, which may enhance the translocation and functional activity of Peroxin 1 in peroxisome assembly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). By activating PKC, PMA can stimulate Peroxin 1's translocation to peroxisomes, where Peroxin 1 functions in peroxisome assembly. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases the levels of cyclic AMP (cAMP). Elevated cAMP activates PKA, which can phosphorylate Peroxin 1 and enhance its functional activity in peroxisome assembly. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA activates G protein-coupled receptors, leading to the activation of the PKC. Activation of PKC can stimulate Peroxin 1's translocation to peroxisomes and enhance its function in peroxisome assembly. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate PKC, which in turn enhances the translocation and function of Peroxin 1 in peroxisome assembly. | ||||||
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
As a secondary messenger, Ca2+ can activate PKC, leading to the translocation of Peroxin 1 to peroxisomes, where it can enhance its functional activity in peroxisome assembly. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
OAG is a synthetic analogue of diacylglycerol (DAG) and activates PKC. This can stimulate Peroxin 1's translocation to peroxisomes and enhance its function in peroxisome assembly. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin binds to and activates various protein kinases, which can phosphorylate Peroxin 1 and enhance its functional activity in peroxisome assembly. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, which potentially sustains the phosphorylation state and thus activation of Peroxin 1, enhancing its function in peroxisome assembly. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Phosphatidylserine can activate PKC, which may enhance the translocation and functional activity of Peroxin 1 in peroxisome assembly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a regulator of vesicle formation in cells. This inhibition can potentially enhance the functional activity of Peroxin 1 by altering intracellular trafficking processes related to peroxisome assembly. | ||||||