Peroxin 1 Antibody (D-9): sc-393174
- Peroxin 1 Antibody (D-9) is a mouse monoclonal IgG1 κ Peroxin 1 antibody provided at 200 µg/ml
- raised against amino acids 601-798 mapping within an internal region of Peroxin 1 of human origin
- Peroxin 1 Antibody (D-9) is recommended for detection of Peroxin 1 of human origin by WB, IP, IF and ELISA
- Anti-Peroxin 1 Antibody (D-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Peroxin 1 Antibody (D-9) for WB applications. These reagents are now offered in bundles with Peroxin 1 Antibody (D-9) (see ordering information below).
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Peroxin 1 Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Peroxin 1 (PEX1) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PEX1 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PEX1 plays a crucial role in peroxisome biogenesis, which is essential for the proper functioning of peroxisomes—organelles that are vital for various metabolic processes, including the breakdown of very long-chain fatty acids and the detoxification of hydrogen peroxide. Specifically, PEX1 is involved in the stability of Pex5, a protein that facilitates the import of other proteins into the peroxisome matrix. This import process is critical because PEX1 ensures that enzymes necessary for fatty acid metabolism and other biochemical pathways are present in the peroxisome, thereby maintaining cellular homeostasis and preventing the accumulation of toxic substances. PEX1 interaction with Pex26 anchors PEX1 to the peroxisome membrane, forming heteromeric AAA ATPase complexes that are indispensable for the import of proteins into peroxisomes. This intricate mechanism highlights PEX1′s importance in cellular metabolism and potential implications in metabolic disorders when peroxisome function is compromised.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Peroxin 1 Antibody (D-9) References:
- Peroxisome biogenesis and peroxisome biogenesis disorders. | Fujiki, Y. 2000. FEBS Lett. 476: 42-6. PMID: 10878247
- The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import. | Collins, CS., et al. 2000. Mol Cell Biol. 20: 7516-26. PMID: 11003648
- Organelle disease: peroxisomal disorders. | Gärtner, J. 2000. Eur J Pediatr. 159 Suppl 3: S236-9. PMID: 11216907
- Cellular and molecular aspects of Zellweger syndrome and other peroxisome biogenesis disorders. | Brosius, U. and Gärtner, J. 2002. Cell Mol Life Sci. 59: 1058-69. PMID: 12169017
- The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly. | Honsho, M., et al. 2002. J Biol Chem. 277: 44513-24. PMID: 12223482
- The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes. | Matsumoto, N., et al. 2003. Nat Cell Biol. 5: 454-60. PMID: 12717447
- The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol. | Costa-Rodrigues, J., et al. 2004. J Biol Chem. 279: 46573-9. PMID: 15328363
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Peroxin 1 Antibody (D-9) | sc-393174 | 200 µg/ml | $322.00 | |||
Peroxin 1 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-527672 | 200 µg Ab; 10 µg BP | $361.00 | |||
Peroxin 1 Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-533045 | 200 µg Ab; 20 µg BP | $361.00 | |||
Peroxin 1 Antibody (D-9) AC | sc-393174 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Peroxin 1 Antibody (D-9) HRP | sc-393174 HRP | 200 µg/ml | $322.00 | |||
Peroxin 1 Antibody (D-9) FITC | sc-393174 FITC | 200 µg/ml | $336.00 | |||
Peroxin 1 Antibody (D-9) PE | sc-393174 PE | 200 µg/ml | $349.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 488 | sc-393174 AF488 | 200 µg/ml | $364.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 546 | sc-393174 AF546 | 200 µg/ml | $364.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 594 | sc-393174 AF594 | 200 µg/ml | $364.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 647 | sc-393174 AF647 | 200 µg/ml | $364.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 680 | sc-393174 AF680 | 200 µg/ml | $364.00 | |||
Peroxin 1 Antibody (D-9) Alexa Fluor® 790 | sc-393174 AF790 | 200 µg/ml | $364.00 |