Per1 Activators
Per1 Activators refer to a class of chemical compounds that modulate the activity of the Period circadian regulator 1 (Per1) gene. The circadian rhythm, an intrinsic biological clock that governs an organism's sleep-wake cycle and other physiological processes, is maintained through an intricate network of genes and proteins. Among these, the Period genes (Per1, Per2, and Per3 in mammals) play a pivotal role in maintaining this rhythm. They transcribe proteins that form complexes and eventually feed back to suppress their own expression, completing a cyclic process that recurs approximately every 24 hours.
Per1 activators, as the name suggests, enhance or stimulate the activity of the Per1 gene. The mechanism of action by which these activators influence the Per1 gene can be diverse, ranging from direct interaction with the gene or its associated regulatory elements, to indirect modulation by affecting pathways that, in turn, regulate Per1 expression or activity. The significance of these activators lies in their ability to potentially reset or adjust the circadian rhythm, especially in situations where it may be disrupted. A precise understanding of these molecules and their interactions can provide insights into the delicate balance of the circadian system and how external or internal factors can influence its regularity.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect several cellular processes, including glycogen synthesis. This action might alter the cellular energy status, which has been suggested to impact circadian genes, including PER1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP can induce the expression of PER1 through activation of the cAMP response element-binding protein (CREB). | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can reset the phase of peripheral clocks. It's been shown to acutely induce PER1 expression in certain cells, possibly via glucocorticoid receptor activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
As an analog of cAMP, 8-Bromo-cAMP can activate CREB, which is involved in the transcriptional activation of the PER1 gene. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can influence intracellular signaling pathways. It has been proposed to upregulate PER1 expression through activation of certain kinases. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has diverse biological effects, and one of them might be the modulation of circadian genes. Some studies have shown that curcumin can increase PER1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can affect gene expression through retinoic acid receptors. It's been shown to influence circadian genes, including the potential induction of PER1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been studied for its effects on various cellular pathways. Some reports indicate its potential in modulating PER1 expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can modulate intracellular cAMP and calcium levels. Through these and other mechanisms, it has the potential to influence the expression of PER1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, commonly associated with its anti-diabetic properties, has been shown to impact circadian gene expression. It might induce PER1 through AMPK-related pathways. | ||||||