Per1 Antibody (E-8): sc-398890

Per1 Antibody (E-8) is a mouse monoclonal IgM antibody that detects Per1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-Per1 antibody (E-8) is available as the non-conjugated form. Per1 protein plays a crucial role in the regulation of circadian rhythms, which are essential for maintaining various physiological processes, including sleep-wake cycles and hormonal secretions. Located primarily in the cytoplasm, the full-length Per1 isoform is vital for function in the cellular clock mechanism, while a shorter nuclear isoform also exists, indicating a complex regulatory role in gene expression. Per1 interaction with other proteins, such as Timeless (Tim), helps modulate the transcriptional activity of the Clock-BMAL1 complex, which is central to circadian rhythm regulation. Mutations in the Clock gene can disrupt these rhythms, leading to various health issues, underscoring the importance of studying Per1 and its interactions. Per1 (E-8) antibody is an invaluable tool for researchers investigating the molecular mechanisms underlying circadian biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Per1 Antibody (E-8) References:

1. Hypoxia affects expression of circadian genes PER1 and CLOCK in mouse brain.  |  Chilov, D., et al. 2001. FASEB J. 15: 2613-22. PMID: 11726537
2. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.  |  Antoch, MP., et al. 1997. Cell. 89: 655-67. PMID: 9160756
3. The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.  |  King, DP., et al. 1997. Genetics. 146: 1049-60. PMID: 9215907
4. Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.  |  Zylka, MJ., et al. 1998. Neuron. 20: 1103-10. PMID: 9655499
5. Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.  |  Sangoram, AM., et al. 1998. Neuron. 21: 1101-13. PMID: 9856465
6. A 24-hour circadian clock is found in the mammalian retina.  |  Morell, V. 1996. Science. 272: 349. PMID: 8602520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Per1 Antibody (E-8) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Per1 Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Per1 Antibody (E-8) Specifications

Alternate Product Name: Period Circadian Regulator 1

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 17-43

Epitope Target: Per1

Epitope Species: human

Product Reactivity/Detection: Per1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Per1 Antibody (E-8): P: Blocking Peptide, X: TransCruz Reagent