Peg10 Activators
Peg10 Activators are a specialized set of chemical compounds that, through various mechanisms, enhance the functional activities of Peg10, which is implicated in cell proliferation and survival. Forskolin serves to elevate intracellular cAMP levels, thereby activating protein kinase A (PKA), which phosphorylates substrates that may include those involved in signaling pathways pertinent to Peg10 function, thus indirectly potentiating Peg10's role in cellular processes. Phorbol 12-myristate 13-acetate (PMA) enhances the activity of protein kinase C (PKC), which could support Peg10's functions by promoting an intracellular milieu that favors its role in growth and differentiation. Moreover, the PI3K inhibitor LY294002 and the MEK inhibitors U0126 and SB203580 could indirectly upregulate Peg10 activity by modulating the cellular signaling equilibrium, thereby creating a favorable context for Peg10's involvement in growth and survival pathways.
The action of A23187 (Calcimycin) in increasing intracellular calcium levels can activate calcium-dependent signaling pathways that, in turn, may indirectly promote Peg10's functional activity due to its association with cellular processes that are modulated by calcium signaling. Genistein's inhibition of tyrosine kinases could relieve competitive inhibition on pathways where Peg10 operates, thus potentially enhancing Peg10's activity. Wnt Agonist 1, by activating the Wnt signaling pathway, would support cellular contexts in which Peg10's role is beneficial, such as in differentiation and proliferation. Lastly, Dibutyryl-cAMP, by mimicking cAMP, activates PKA and enhances Peg10-related cellular functions, which include but may not be limited to, cellular proliferation, thereby indirectly contributing to the enhancement of Peg10's activity in the cell. Collectively, these chemical activators work through different but interconnected signaling pathways to enhance the functional activities of Peg10 without directly increasing its expression or directly activating it, instead shaping the cellular signaling landscape in a way that promotes Peg10's roles in cell growth and survival.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This polyphenol from green tea inhibits DNA methyltransferases, which could reduce methylation at the PEG10 locus, potentially leading to its increased expression and functional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuins, which are known to modulate longevity and stress resistance pathways. Increased sirtuin activity may reduce stress-mediated silencing of PEG10, thus enhancing its function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
As a histone deacetylase inhibitor, Sodium Butyrate can lead to a more open chromatin structure around the PEG10 gene, potentially enhancing its transcription and subsequent protein function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA demethylating agent could potentially reactivate silenced genes including PEG10 by reducing methylation levels, leading to its functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid acts on nuclear receptors and can modulate gene expression. It may influence the expression of PEG10 through retinoic acid response elements. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases cAMP levels, which can activate PKA. PKA activation can lead to changes in transcriptional activity, potentially including upregulation of PEG10. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a primary estrogen, Beta-Estradiol can bind to estrogen receptors and influence gene expression patterns, which could include the upregulation of PEG10 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is another histone deacetylase inhibitor which can lead to increased acetylation of histones and an open chromatin state, potentially enhancing PEG10 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate a variety of signaling pathways and may influence PEG10 expression through its effects on transcription factor activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences the Wnt signaling pathway, which could potentially interact with PEG10 expression and activation due to the pathway's wide-ranging effects on gene expression. | ||||||