PEA3 Inhibitors
PEA3 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the PEA3 transcription factors. PEA3, which stands for Polyomavirus Enhancer Activator 3, refers to a family of transcription factors that play a pivotal role in regulating gene expression. These transcription factors are vital for various cellular processes, including embryonic development, tissue regeneration, and cancer progression. PEA3 factors are known to interact with specific DNA sequences within the promoter regions of target genes, thereby influencing their transcription. By inhibiting PEA3 activity, PEA3 inhibitors disrupt the normal functioning of these genes and the cellular pathways they govern.
PEA3 inhibitors are often designed to act as small molecules that can specifically bind to the PEA3 transcription factors or interfere with their interaction with DNA. This interference can lead to a decrease in the expression of genes regulated by PEA3, which may have downstream effects on cell growth, differentiation, and migration. The development of PEA3 inhibitors has garnered significant interest in the field of molecular biology and drug discovery, as they hold promise for studying the mechanisms underlying various cellular processes and in conditions where PEA3 transcription factors play a role. Understanding the precise mechanisms by which PEA3 inhibitors modulate gene expression is crucial for elucidating their broader impact on cellular physiology and uncovering avenues for future research and development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a component of the spice turmeric, may suppress PEA3 expression by modulating various signaling pathways such as the NF-κB pathway, which is involved in the transcription of numerous genes including those related to cell survival and proliferation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to exhibit anti-inflammatory and anticancer activities. It may inhibit PEA3 expression through its interference with various signaling pathways, including those that regulate transcription factors involved in tumor growth and metastasis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid found in many plants, can modulate signal transduction pathways that affect transcription factors, potentially leading to decreased expression of PEA3 by affecting its mRNA stability or inhibiting upstream signals that activate its expression. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Found in cruciferous vegetables, indole-3-carbinol may alter PEA3 expression by affecting estrogen receptor signaling, which can modulate the expression of various genes including those associated with cell growth. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound in cruciferous vegetables that can inhibit histone deacetylase, potentially downregulating PEA3 expression through changes in chromatin structure and gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, may downregulate PEA3 expression by influencing multiple signaling pathways, including the MAPK and PI3K/Akt pathways, which can modulate the activity of transcription factors and gene expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
As a phytoestrogen, genistein may inhibit PEA3 expression by modulating hormone receptor signaling pathways, which can alter the transcription of various genes involved in cell proliferation and survival. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $36.00 $64.00 $87.00 $413.00 $668.00 $65.00 | 8 | |
DIM, a metabolite of indole-3-carbinol, may impact PEA3 expression by modulating androgen receptor signaling. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol may suppress the expression of PEA3 through its anti-inflammatory effects, potentially affecting transcription factors that are regulated by inflammatory signaling pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin, the active component in chili peppers, may reduce PEA3 expression by altering signal transduction pathways involved in cancer cell metabolism and apoptosis. | ||||||