PDZK7 Inhibitors
Chemical inhibitors of PDZK7 serve to modulate its activity within various cellular signaling pathways. Staurosporine, a broad-spectrum protein kinase inhibitor, can disrupt the phosphorylation processes essential to PDZK7's interactions with other proteins. GW5074, which specifically targets c-Raf kinase, can impede PDZK7 by obstructing the c-Raf-mediated pathways upon which PDZK7 may depend for its operation. Additionally, SP600125, by inhibiting the c-Jun N-terminal kinase (JNK), can prevent PDZK7 from engaging in JNK signaling pathways that are necessary for its function or stability within the cellular context.
Further inhibitory effects on PDZK7 can be achieved with LY294002 and Wortmannin, both of which are phosphoinositide 3-kinases (PI3K) inhibitors. By targeting PI3K, these inhibitors can interfere with signaling cascades that regulate PDZK7. Similarly, U0126 and PD98059, as inhibitors of the MEK enzyme, can disrupt the MEK/ERK pathway, which is likely relevant to the regulation of PDZK7's role in the cell. SB203580, targeting the p38 MAP kinase, can affect PDZK7 by altering the p38 MAPK pathway. Inhibitors like Lapatinib and Erlotinib, which target EGFR and HER2, can inhibit PDZK7 by blocking the signaling routes these receptors control and which PDZK7 may utilize. Lastly, PP2, an Src family kinase inhibitor, and SU5402, an FGFR1 inhibitor, can suppress PDZK7 activity by obstructing Src kinase and FGFR1-mediated signaling, respectively, which PDZK7 may be involved in.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits protein kinases which are crucial in signaling pathways that PDZK7 is involved in. By inhibiting these kinases, Staurosporine can impede the phosphorylation events that are necessary for PDZK7's functional interactions with other proteins. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a c-Raf kinase inhibitor. PDZK7 can be functionally inhibited by GW5074 as it may rely on c-Raf-mediated signaling for its proper function within cellular signaling networks, and inhibition of c-Raf kinase would disrupt these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). PDZK7's function can be inhibited by SP600125 by disrupting JNK signaling pathways, which may be necessary for PDZK7's activity or stability in cells. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PDZK7 can be inhibited by LY294002 as PI3K signaling is often linked to the regulation and function of PDZ domain-containing proteins, which may affect PDZK7's role in cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase (MEK). PDZK7 can be inhibited by U0126 through the disruption of MEK/ERK signaling pathway, which may be involved in the regulation of PDZK7's function or expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. PDZK7's function can be inhibited by SB203580 by impairing the p38 MAPK pathway, which could be involved in the signaling pathways that regulate PDZK7's cellular role. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, similar to LY294002. PDZK7 can be inhibited by Wortmannin by inhibiting PI3K-dependent signaling pathways that could contribute to the functional regulation of PDZK7. | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Lapatinib is an EGFR and HER2 inhibitor. PDZK7 can be inhibited by Lapatinib as it may interact with or be regulated by EGFR/HER2 signaling pathways, and inhibition of these receptors could disrupt PDZK7's function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. PDZK7's function can be inhibited by PP2 as Src kinase signaling may modulate PDZK7 activity or its interaction with other proteins in the cell. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an MEK inhibitor, similar to U0126. PDZK7 can be inhibited by PD98059 by disrupting the MEK/ERK signaling pathway, potentially affecting PDZK7's role in cellular signaling. | ||||||