PDXDC2 Activators
Forskolin increases intracellular cAMP levels, a second messenger that plays a crucial role in the activation of protein kinase A (PKA). PKA can then phosphorylate various proteins, including PDXDC2, if it is a substrate. This phosphorylation can lead to conformational changes that affect protein activity. Ionomycin, as a calcium ionophore, can markedly elevate intracellular calcium levels, which in turn activates calcium-dependent protein kinases. These kinases have a broad range of substrates and can modulate PDXDC2 through phosphorylation. PMA specifically targets protein kinase C (PKC) for activation. PKC is a family of protein kinases with varied substrate specificities, which can lead to the phosphorylation and activation of PDXDC2 if it lies within PKC's scope. IBMX works by inhibiting phosphodiesterases, which degrade cAMP. The resultant increase in cAMP levels can further stimulate PKA activity, creating a conducive environment for PDXDC2 activation through phosphorylation.
Epigallocatechin gallate and resveratrol engage with multiple signaling pathways, influencing kinase activities that can cascade down to affect PDXDC2. Sildenafil's role in inhibiting phosphodiesterase type 5 (PDE5) leads to elevated cGMP levels, which can activate protein kinases that might target PDXDC2. LY294002, by inhibiting PI3K, and PD98059, by inhibiting MEK, can cause alterations in the PI3K/AKT and MAPK pathways, respectively. These pathways are integral to many cellular processes, including the phosphorylation state of proteins, which could encompass PDXDC2. Sodium fluoride's inhibition of phosphatases results in increased phosphorylation levels, which may favor PDXDC2's active state. Genistein and curcumin are known for their ability to modulate kinase signaling cascades. Genistein's inhibition of tyrosine kinases can lead to altered phosphorylation patterns that may upregulate PDXDC2 activity. Curcumin, through its interaction with various signaling molecules, can affect regulatory pathways that modulate the function and activity of PDXDC2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase to increase cAMP, which can activate PKA leading to phosphorylation events influencing PDXDC2. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Raises intracellular calcium levels, activating calcium-dependent kinases that can phosphorylate and regulate PDXDC2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Directly activates PKC, which may target PDXDC2 for phosphorylation and activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits phosphodiesterases, increasing cAMP levels, which can enhance PKA activity and subsequently PDXDC2 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Modulates signal transduction pathways, possibly leading to changes in PDXDC2 activity via secondary effects. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Influences various signaling pathways, which can lead to activation of kinases that regulate PDXDC2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that can modulate downstream signaling pathways, potentially affecting PDXDC2 activity indirectly. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, leading to changes in MAPK pathway activity, which can influence PDXDC2 phosphorylation and activation. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Inhibits phosphatases, leading to a net increase in phosphorylation within the cell, which can enhance PDXDC2 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that can modulate phosphorylation cascades, potentially affecting PDXDC2 activity. | ||||||