Date published: 2026-4-1

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PDSS2 Activators

PDSS2 activators belong to a specialized class of chemical compounds known for their ability to modulate the activity of the Protein Disease Susceptibility 2 (PDSS2) enzyme. PDSS2, also referred to as prenyl diphosphate synthase subunit 2, is a crucial component of the mitochondrial biosynthesis pathway responsible for producing isoprenoid molecules, particularly ubiquinone or coenzyme Q10 (CoQ10). CoQ10 is an essential electron carrier in the mitochondrial respiratory chain, facilitating ATP production and acting as a potent antioxidant. PDSS2 activators are meticulously designed to interact with PDSS2, potentially influencing its enzymatic function and affecting the biosynthesis of CoQ10. At the molecular level, these activators may modulate the binding of substrates, cofactors, or other regulatory molecules to PDSS2.

Research on PDSS2 activators is significant for advancing our understanding of mitochondrial biology, energy production, and oxidative stress defense mechanisms. Scientists in this field primarily focus on elucidating the precise molecular mechanisms by which these compounds impact PDSS2's function and their downstream effects on CoQ10 biosynthesis and mitochondrial function. CoQ10 plays a critical role in cellular energy metabolism and serves as a vital component in maintaining mitochondrial health. Moreover, these compounds serve as valuable tools for researchers seeking to investigate the molecular basis of CoQ10 biosynthesis and its implications in various physiological contexts, ultimately deepening our understanding of mitochondrial biochemistry and its impact on cellular energy homeostasis and oxidative stress defense.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Enhances mitochondrial function and biogenesis, potentially upregulating PDSS2 to meet increased CoQ10 demands.

1,1-Dimethylbiguanide, Hydrochloride

1115-70-4sc-202000F
sc-202000A
sc-202000B
sc-202000C
sc-202000D
sc-202000E
sc-202000
10 mg
5 g
10 g
50 g
100 g
250 g
1 g
$20.00
$43.00
$63.00
$156.00
$260.00
$510.00
$31.00
37
(1)

Activates AMPK, promoting mitochondrial biogenesis and possibly influencing PDSS2.

AICAR

2627-69-2sc-200659
sc-200659A
sc-200659B
50 mg
250 mg
1 g
$65.00
$280.00
$400.00
48
(2)

AMPK activator; might indirectly boost PDSS2 expression by promoting mitochondrial biogenesis.

β-Nicotinamide mononucleotide

1094-61-7sc-212376
sc-212376A
sc-212376B
sc-212376C
sc-212376D
25 mg
100 mg
1 g
2 g
5 g
$110.00
$150.00
$220.00
$300.00
$600.00
4
(1)

NAD+ precursor enhancing mitochondrial function; could indirectly influence PDSS2.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

mTOR inhibitor; might enhance mitochondrial function in certain contexts, indirectly influencing PDSS2.

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$120.00
$326.00
$634.00
$947.00
$1259.00
38
(1)

Promotes mitochondrial biogenesis, potentially influencing PDSS2 expression.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Enhances antioxidant responses, possibly upregulating PDSS2 as part of a broader cellular protective response.

Nicotinamide riboside

1341-23-7sc-507345
10 mg
$411.00
(0)

Another NAD+ precursor; might indirectly boost PDSS2 expression by enhancing mitochondrial function.

2,4-Dinitrophenol, wetted

51-28-5sc-238345
250 mg
$59.00
2
(1)

Mitochondrial uncoupler; the increased demand for oxidative phosphorylation might induce PDSS2 to meet CoQ10 demands.

Pioglitazone

111025-46-8sc-202289
sc-202289A
1 mg
5 mg
$55.00
$125.00
13
(1)

PPAR-γ agonist; could influence PDSS2 by promoting mitochondrial biogenesis and function.