PDSS2 Antibody (C-12): sc-515137
- PDSS2 Antibody (C-12) is a mouse monoclonal IgG1 κ PDSS2 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 100-399 mapping at the C-terminus of PDSS2 of human origin
- PDSS2 Antibody (C-12) is recommended for detection of PDSS2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PDSS2 Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PDSS2 (C-12): sc-515137.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDSS2 Antibody (C-12). This work is in progress.
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PDSS2 Antibody (C-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects PDSS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDSS2 (C-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Prenyl Diphosphate Synthase subunit 2 (PDSS2), also known as decaprenyl-diphosphate synthase subunit 2, decaprenyl pyrophosphate synthetase subunit 2, and candidate tumor suppressor protein, is a 399 amino acid protein that plays a crucial role in the biosynthesis of coenzyme Q10, a vital component of the electron transport chain in mitochondria. PDSS2 function is particularly important as coenzyme Q10 is essential for cellular energy production and has antioxidant properties, which help protect cells from oxidative stress. Defects in PDSS2 can lead to coenzyme Q10 deficiency, resulting in severe clinical manifestations such as myopathy, encephalomyopathy, and ataxia, highlighting PDSS2′s significance in maintaining cellular health. The gene encoding PDSS2 is located on chromosome 6q21, and alternative splicing results in two isoforms of PDSS2, further emphasizing its complexity and potential regulatory mechanisms in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDSS2 Antibody (C-12) References:
- Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. | Saiki, R., et al. 2005. FEBS J. 272: 5606-22. PMID: 16262699
- Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. | López, LC., et al. 2006. Am J Hum Genet. 79: 1125-9. PMID: 17186472
- Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. | Hom, JR., et al. 2007. J Cell Physiol. 212: 498-508. PMID: 17443673
- CoQ10 deficiency diseases in adults. | Quinzii, CM., et al. 2007. Mitochondrion. 7 Suppl: S122-6. PMID: 17485248
- Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2. | Saiki, R., et al. 2008. Am J Physiol Renal Physiol. 295: F1535-44. PMID: 18784258
- Human CoQ10 deficiencies. | Quinzii, CM., et al. 2008. Biofactors. 32: 113-8. PMID: 19096106
- Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21. | Fung, JM., et al. 2009. Clin Cancer Res. 15: 797-803. PMID: 19188149
- Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line. | Chen, P., et al. 2009. Anticancer Drugs. 20: 141-8. PMID: 19209031
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDSS2 Antibody (C-12) | sc-515137 | 200 µg/ml | $316.00 | |||
PDSS2 Antibody (C-12) AC | sc-515137 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PDSS2 Antibody (C-12) HRP | sc-515137 HRP | 200 µg/ml | $316.00 | |||
PDSS2 Antibody (C-12) FITC | sc-515137 FITC | 200 µg/ml | $330.00 | |||
PDSS2 Antibody (C-12) PE | sc-515137 PE | 200 µg/ml | $343.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 488 | sc-515137 AF488 | 200 µg/ml | $357.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 546 | sc-515137 AF546 | 200 µg/ml | $357.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 594 | sc-515137 AF594 | 200 µg/ml | $357.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 647 | sc-515137 AF647 | 200 µg/ml | $357.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 680 | sc-515137 AF680 | 200 µg/ml | $357.00 | |||
PDSS2 Antibody (C-12) Alexa Fluor® 790 | sc-515137 AF790 | 200 µg/ml | $357.00 |