PDCL2 Activators
PDCL2 activators are a class of chemical compounds that interact with the protein disulfide isomerase family A, member 3 (PDIA3), also known as PDCL2, which is an enzyme that plays a significant role in protein folding within the endoplasmic reticulum. The activation of PDCL2 involves the enhancement of its isomerase activity, which is crucial for the correct formation of disulfide bonds in nascent proteins. This biochemical process is essential for maintaining homeostasis within cells, as it ensures that proteins attain their proper three-dimensional structures, which are necessary for their stability and functionality. PDCL2 activators are recognized for their ability to modulate this protein's activity, thus influencing protein folding mechanisms.
The chemical structure of PDCL2 activators is designed to bind selectively to the PDCL2 enzyme, which can lead to an alteration in the enzyme's conformation and subsequently affect its interaction with substrate proteins. The binding of these activators to PDCL2 can influence the rate at which the enzyme catalyzes the rearrangement of disulfide bonds in substrate proteins. The activation of PDCL2 by these compounds is a subject of interest in the field of biochemistry and cell biology due to the central role of protein folding in cellular function. Research into PDCL2 activators encompasses the exploration of their molecular properties, including their affinity for the PDCL2 enzyme, their stability, and the specificity of their action. These activators are not only relevant for understanding the intricate details of protein folding but also provide insights into the regulation of the physiological pathways associated with PDCL2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene that activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. The rise in cAMP can activate PKA (protein kinase A), which in turn can phosphorylate and enhance the activity of PDCL2, particularly if PDCL2 activity is regulated by phosphorylation events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Upon activation, PKC can phosphorylate various substrate proteins, potentially including PDCL2 if it is under the regulation of PKC-mediated phosphorylation. This can lead to an enhancement of PDCL2 functional activity within cells. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases. These kinases might phosphorylate PDCL2, leading to its activation if PDCL2 is a substrate for calcium-dependent phosphorylation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence gene expression by activating nuclear receptors. If PDCL2 function is modulated by proteins that are transcriptionally regulated by retinoic acid, it could lead to an indirect enhancement of PDCL2 activity by stabilizing the protein or facilitating its proper folding and function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase-inhibiting properties. By inhibiting certain kinases, EGCG could reduce negative regulatory phosphorylation events on PDCL2, leading to enhanced activity if PDCL2 is normally inhibited by such phosphorylations. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol is an inhibitor of Syk kinase. If Syk kinase negatively regulates PDCL2 activity through phosphorylation, inhibition by piceatannol could lift this negative regulation, leading to an increase in PDCL2 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases could prevent dephosphorylation of PDCL2, maintaining it in a phosphorylated and activated state if its activity is modulated by phosphorylation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This cAMP analog can activate protein kinase A (PKA) by mimicking cAMP. Activated PKA could phosphorylate PDCL2, thereby enhancing its activity if PDCL2 is regulated by PKA-mediated phosphorylation. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
SNAP is a nitric oxide (NO) donor. NO can activate guanylate cyclase, increasing intracellular cGMP levels, which can activate protein kinase G (PKG). If PDCL2 is subject to regulation by PKG-mediated phosphorylation, NO donation by SNAP could lead to the enhancement of PDCL2 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, but at low concentrations, it can act selectively on certain kinases. If PDCL2 is indirectly activated by the inhibition of a kinase that negatively regulates its activity, staurosporine could enhance PDCL2 activity by lifting such inhibition. | ||||||