PCDHGA4 Inhibitors
The chemical class termed PCDHGA4 Inhibitors is designed to selectively modulate the activity of protocadherin gamma subfamily A member 4 (PCDHGA4). Protocadherins, a family of cell adhesion molecules, are integral to numerous cellular processes, particularly in the development and maintenance of neural circuits. PCDHGA4, as a member of the protocadherin gamma subfamily, is hypothesized to contribute to mediating cell-cell interactions crucial for the intricate wiring of the nervous system. Inhibitors targeting PCDHGA4 operate by interfering with its normal functions, disrupting the complex molecular interactions and signaling pathways in which PCDHGA4 is engaged. This interference may lead to alterations in cell adhesion patterns and could impact cellular communication processes governed by PCDHGA4.
The mechanism of action for PCDHGA4 inhibitors involves their selective binding to PCDHGA4, modulating its activity and potentially influencing downstream cellular processes. These inhibitors serve as valuable tools for researchers aiming to elucidate the specific functions of protocadherins within the broader landscape of cellular biology, especially in the intricate processes of neural development and synaptic connectivity. The study of PCDHGA4 inhibitors, in this theoretical scenario, contributes to our understanding of the regulatory mechanisms that govern cell adhesion and communication, providing insights into the complex molecular processes involved in the formation and maintenance of neuronal networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is a nucleoside analog that inhibits DNA polymerase, possibly leading to decreased PCDHGA4 transcription. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is a dihydrofolate reductase inhibitor that affects nucleotide synthesis, potentially reducing PCDHGA4 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, impairing DNA synthesis which could result in reduced transcription of PCDHGA4. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide interferes with DNA topoisomerase II, leading to DNA damage and possibly decreased expression of genes like PCDHGA4. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacitidine is a nucleoside analog that can be incorporated into RNA and DNA, potentially disrupting PCDHGA4 mRNA synthesis. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C forms crosslinks in DNA, potentially inhibiting the transcription machinery from accessing the PCDHGA4 gene. | ||||||
Topotecan Hydrochloride | 119413-54-6 | sc-204919 sc-204919A | 1 mg 5 mg | $44.00 $100.00 | 2 | |
Topotecan inhibits topoisomerase I, preventing DNA unwinding and potentially suppressing PCDHGA4 expression. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $89.00 $250.00 | 32 | |
Temozolomide alkylates/methylates DNA, which may lead to the mispairing of nucleotides and hinder PCDHGA4 transcription. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $45.00 $87.00 | 2 | |
Mebendazole disrupts microtubule function, which can lead to cell cycle arrest and may affect PCDHGA4 expression indirectly. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, affecting various cellular pathways and possibly downregulating PCDHGA4 expression. | ||||||