Molecular structure of Mebendazole, CAS Number: 31431-39-7
Mebendazole (CAS 31431-39-7)
See product citations (2)
Alternate Names:
5-Benzoyl-2-benzimidazolecarbamic acid methyl ester
Application:
Mebendazole is an antihelmintic small molecule compound
CAS Number:
31431-39-7
Purity:
≥98%
Molecular Weight:
295.29
Molecular Formula:
C16H13N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mebendazole is a synthetic benzimidazole derivative. Its mechanism of action involves impeding the formation of microtubules within the cells of the parasites. By targeting the beta-tubulin subunit of microtubules, Mebendazole inhibits their formation, impeding the growth and reproduction of the parasites. Furthermore, Mebendazole exhibits a diverse array of biochemical and physiological effects. It hinders the synthesis of DNA, RNA, and proteins, while also curtailing the uptake of vital nutrients by the parasites.
Mebendazole (CAS 31431-39-7) References
- Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. | Bennett, A. and Guyatt, H. 2000. Parasitol Today. 16: 71-4. PMID: 10652492
- Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. | Dayan, AD. 2003. Acta Trop. 86: 141-59. PMID: 12745134
- Repurposing mebendazole for the treatment of medulloblastoma. | Bodhinayake, I., et al. 2015. Neurosurgery. 76: N15-6. PMID: 25594199
- A review of pharmacokinetic drug-drug interactions with the anthelmintic medications albendazole and mebendazole. | Pawluk, SA., et al. 2015. Clin Pharmacokinet. 54: 371-83. PMID: 25691367
- Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors. | De Witt, M., et al. 2017. Mol Med. 23: 50-56. PMID: 28386621
- Mebendazole inhibits tumor growth and prevents lung metastasis in models of advanced thyroid cancer. | Williamson, T., et al. 2020. Endocr Relat Cancer. 27: 123-136. PMID: 31846433
- Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial. | Gallia, GL., et al. 2021. Neurooncol Adv. 3: vdaa154. PMID: 33506200
- Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update. | Chai, JY., et al. 2021. Korean J Parasitol. 59: 189-225. PMID: 34218593
- Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer. | Williamson, T., et al. 2021. Oncotarget. 12: 1326-1338. PMID: 34262644
- Safety and Tolerability of Mebendazole in Infants Under 1 Year of Age. | Kahan, Y., et al. 2021. J Pediatric Infect Dis Soc.. PMID: 34468731
- Mebendazole's Conformational Space and Its Predicted Binding to Human Heat-Shock Protein 90. | Fiedler, W., et al. 2022. J Chem Inf Model. 62: 3604-3617. PMID: 35867562
- Mebendazole in the treatment of helminthiasis. | Seah, SK. 1976. Can Med Assoc J. 115: 777-9. PMID: 974969
- Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis. | Ammann, RW., et al. 1998. J Hepatol. 29: 994-8. PMID: 9875648
Inhibitor of:
α3d Tubulin, β-Tubulin, β2C Tubulin, β4 Tubulin, β4Q Tubulin, β6 Tubulin, β8 Tubulin, 1700019B03Rik, 6330545A04Rik, 9530077C05Rik, A730037C10Rik, Actin related protein 2/3 (ARP2/3), ANKT, BART1, BBS10, BBS4, BBS7, Bestrophin-3, C10orf92, C17orf98, CAMSAP1, CCDC74A, CENP-N, CENP-V, CLCA2, CMG, EAN57, Echinococcus granulosus, GCP4, GCP6, GTL3, HYDIN, IFT20, IFT52, IFT81, Katanin p60 AL2, KIAA1683, LGALS9B, MZT1, NF-L, nudel, oskar, PCDHGA4, periphilin 1, REEP1, RGPD3, SDCCAG8, SPAG17, Spastin, Tβ-10, TAX-4, TC1, Tctex1D1, TDRD6, Tektin 5, TMEM216, TMEM231, TPPP, TPPP2, TPPP3, TTC26, TTC27, TTC30A, TTLL1, TTLL5, TTLL6, TTLL8, TUBAL3, VMA21, WDR19, WDR35, WDR60, and Wnt-3.Activator of:
C17orf98, CYP26A1, KIAA1009, KIF2C, and Prickle4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mebendazole, 5 g | sc-204798 | 5 g | $45.00 | |||
Mebendazole, 25 g | sc-204798A | 25 g | $87.00 |