PCDHA10 Activators

PCDHA10, or Protocadherin Alpha 10, is a member of the protocadherin family, a group of molecules that play crucial roles in the nervous system, particularly in neural development and function. This gene is part of the protocadherin alpha gene cluster, one of three related clusters all residing within the human chromosome 5. These clusters are notable for their involvement in the formation of neural circuits and for their unique expression patterns in the nervous system.PCDHA10, like other protocadherins, is characterized by its cadherin domains, which are key for cell-cell adhesion. This adhesion is essential for the proper formation and maintenance of synapses in the brain. The protein encoded by this gene is a single-pass type I membrane protein, meaning it crosses the cell membrane once and has most of its structure outside the cell. This positioning allows it to interact with other cells and proteins in the extracellular environment.

The expression of PCDHA10 is highly specific to the brain and has been implicated in various neural processes, including synaptic plasticity, which is the ability of synapses to strengthen or weaken over time. This plasticity is fundamental to learning and memory.Additionally, PCDHA10 and other protocadherins are involved in the establishment of specific neural connections during brain development. Abnormalities in these proteins can lead to various neurological disorders, highlighting their importance in brain health and function.Overall, PCDHA10 is a crucial component in the complex network of molecular interactions that underpin the development, function, and plasticity of the nervous system.