Molecular structure of D-Serine, CAS Number: 312-84-5
D-Serine (CAS 312-84-5)
Alternate Names:
β-Hydroxyalanine; (R)-2-Amino-3-hydroxypropionic acid; H-D-Ser-OH
Application:
D-Serine is a non-essential amino acid involved in the biosynthesis of amino acids
CAS Number:
312-84-5
Purity:
≥98%
Molecular Weight:
105.09
Molecular Formula:
C3H7NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
D-Serine is a non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine, and is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor.
D-Serine (CAS 312-84-5) References
- NMDA receptor regulation by D-serine: new findings and perspectives. | Wolosker, H. 2007. Mol Neurobiol. 36: 152-64. PMID: 17952659
- Up-regulation of D-serine might induce GABAergic neuronal degeneration in the cerebral cortex and hippocampus in the mouse pilocarpine model of epilepsy. | Liu, YH., et al. 2009. Neurochem Res. 34: 1209-18. PMID: 19123037
- Effects of low-dose D-serine on recognition and working memory in mice. | Bado, P., et al. 2011. Psychopharmacology (Berl). 218: 461-70. PMID: 21556803
- An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures. | Radzishevsky, I. and Wolosker, H. 2012. Methods Mol Biol. 794: 291-7. PMID: 21956571
- Amperometric microbiosensor as an alternative tool for investigation of D-serine in brain. | Mohd Zain, Z., et al. 2012. Amino Acids. 43: 1887-94. PMID: 22865247
- Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase. | Miyoshi, Y., et al. 2012. Amino Acids. 43: 1919-31. PMID: 22990841
- D-serine influences synaptogenesis in a p19 cell model. | Fuchs, SA., et al. 2012. JIMD Rep. 6: 47-53. PMID: 23430939
- D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain. | Balu, DT., et al. 2014. Cell Mol Neurobiol. 34: 419-35. PMID: 24436034
- Effects of D-serine on bacterial D-amino acid transaminase: accumulation of an intermediate and inactivation of the enzyme. | Martinez del Pozo, A., et al. 1989. Biochemistry. 28: 8798-803. PMID: 2513882
- Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. | Ishiwata, S., et al. 2015. J Neural Transm (Vienna). 122: 1099-103. PMID: 25782690
- The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis. | Wolosker, H., et al. 2016. Trends Neurosci. 39: 712-721. PMID: 27742076
- Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. | Papouin, T., et al. 2017. Neuron. 94: 840-854.e7. PMID: 28479102
- Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. | Adamsky, A., et al. 2018. Cell. 174: 59-71.e14. PMID: 29804835
- D-Serine, the Shape-Shifting NMDA Receptor Co-agonist. | Coyle, JT., et al. 2020. Neurochem Res. 45: 1344-1353. PMID: 32189130
- D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism. | Seki, N., et al. 2022. iScience. 25: 104838. PMID: 35996581
Inhibitor of:
ASCT1, ASCT2, PGDH, SAPAP1, and SLC38A7.Activator of:
Cerebellin 2, connexin 39, DAAO, dendrin, DISC-1, DPEP2, EAAT3, EG632778, GluR-δ1, GlyT1, GRIN2, GRINA, Gtlf3b, NAALAD2, NAALADL2, NMDA, NMDAε1, NMDAε3, NMDAε4, NMDAζ1, NR3B, PCDHA10, PSD2, Serine racemase, and Vmn2r13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D-Serine, 5 g | sc-391671 | 5 g | $43.00 | |||
D-Serine, 25 g | sc-391671A | 25 g | $128.00 | |||
D-Serine, 100 g | sc-391671B | 100 g | $204.00 |