Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.
Effect of l-carnitine chloride and its acetyl derivative on the electrophysiological derangement induced by palmityl-l-carnitine in isolated canine ventricular muscle: K. Matsui, et al.; Jpn. J. Pharmacol. 39, 263 (1985)
Soluble in water (100 mg/ml), alcohol, and ethanol (10%). Insoluble in ether.
Store at 4° C
194° C (dec.)
α20/D -28°, c = 2 in water; α20/D°
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Galeotti N; et alGaleotti N; et al. (PubMed ID: 15223307) determined that Acetyl-L-carnitine chloride induced analgesia in mice must activate the PLC-IP(3) pathway to have an effect. -SCBT Publication Review
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