PC1 Activators
PC1 Activators are a suite of chemical compounds that indirectly promote the functional activity of PC1 through a variety of cellular signaling pathways, predominantly involving the cyclic AMP (cAMP) second messenger system. Compounds such as Forskolin, Isoproterenol, Glucagon, Terbutaline, and Salmeterol exert their effects by activating adenylate cyclase or binding to beta-adrenergic receptors, which in turn increases intracellular levels of cAMP. The rise in cAMP activates protein kinase A (PKA), which is known to phosphorylate target proteins and can lead to the enhanced activity of PC1 by either direct phosphorylation or by modifying the phosphorylation state of proteins within PC1's signaling network.
Similarly, the inhibition of phosphodiesterases, which degrade cAMP, by IBMX, Rolipram, Anagrelide, Cilostamide, Zardaverine, and Milrinone also results in an increase in cAMP levels, thereby sustaining PKA activity and promoting an environment conducive to the functional enhancement of PC1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. This elevation of cAMP enhances PC1 activity through PKA activation which can phosphorylate PC1 or its associated proteins, thereby increasing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. Elevated cAMP levels promote PKA-mediated signaling cascades that can enhance the activity of PC1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic sympathomimetic amine that acts as a non-selective beta-adrenergic receptor agonist, leading to increased cAMP and activation of PKA, which can enhance PC1 activity through downstream signaling effects. | ||||||
Pindolol | 13523-86-9 | sc-204847 sc-204847A | 100 mg 1 g | $194.00 $760.00 | ||
Pindolol is a beta-blocker with intrinsic sympathomimetic activity, potentially leading to slight increases in cAMP in certain contexts, which would then activate PKA and could enhance PC1 activity by phosphorylation of associated proteins. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels and subsequent activation of PKA that could enhance the activity of PC1 through phosphorylation. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits phosphodiesterase III, leading to increased cAMP and activation of PKA, potentially enhancing PC1 activity through phosphorylation of regulatory proteins. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a selective inhibitor of phosphodiesterase 3 (PDE3), which increases cAMP levels, possibly enhancing PC1 activity through PKA-dependent signaling pathways. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a dual inhibitor of phosphodiesterase 3 and 4, increasing cAMP levels, which could enhance PC1 activity by activating PKA and leading to the phosphorylation of proteins involved in PC1's signaling pathway. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a selective PDE3 inhibitor, leading to increased intracellular cAMP and activation of PKA, which may enhance PC1 activity indirectly through phosphorylation of associated signaling proteins. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that increases cAMP in cells, thereby activating PKA, which could indirectly enhance the activity of PC1 via phosphorylation of associated proteins. | ||||||