PC-PLD Activators
SEE ALSO...
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate functions as a potent signaling molecule, engaging in specific interactions with cell surface receptors. Its unique structure promotes strong hydrogen bonding and hydrophobic interactions, influencing cellular pathways such as proliferation and migration. The compound's reactivity is characterized by its ability to rapidly modulate lipid bilayer properties, affecting membrane fluidity and organization, which plays a crucial role in cellular communication and response mechanisms. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as a ligand for retinoic acid receptors, which upon activation, can upregulate transcription of genes involved in cellular differentiation and proliferation, potentially including PC-PLD. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
D-erythro-Sphingosine acts as a key modulator in lipid metabolism, influencing the activity of phospholipase D. Its structural configuration allows for specific interactions with membrane components, facilitating the hydrolysis of phosphatidylcholine. This process generates bioactive lipids that participate in intracellular signaling cascades. The compound's amphipathic nature enhances its integration into lipid bilayers, impacting membrane dynamics and cellular signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA mimics diacylglycerol, a physiological activator of protein kinase C (PKC). PKC, once activated, may enhance transcription of PC-PLD by promoting the initiation of signaling cascades that culminate in gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, resulting in elevated cAMP levels that activate protein kinase A (PKA), which can then phosphorylate transcription factors, leading to an increased expression of PC-PLD. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA can be incorporated into cell membrane phospholipids, altering the membrane's physical properties and the activity of membrane-associated enzymes, which could stimulate PC-PLD expression through altered cellular signals. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $128.00 $294.00 | 10 | |
PAF engages its receptor to trigger a signaling cascade that can lead to the activation of various kinases and transcription factors, which may specifically stimulate the transcription of the PC-PLD gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), leading to stabilization of β-catenin, which may translocate to the nucleus and induce the expression of target genes including PC-PLD. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, by inhibiting phosphodiesterases, maintains elevated levels of cAMP, which can enhance the activation of response elements in the promoter regions of genes, possibly including those that increase PC-PLD expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone binds to glucocorticoid receptors, which may then translocate to the nucleus and bind to glucocorticoid response elements, stimulating the expression of target genes, including possibly PC-PLD. | ||||||