PBK Activators
Kinase activators and their mechanisms offer insight into how cellular signaling can be modulated at a post-translational level. ATP analogs, for instance, can enhance the kinase activity of Lymphokine-activated killer T-cell-originated protein kinase by providing alternative substrates for phosphorylation. This can lead to increased substrate turnover and enhanced signaling cascades. Similarly, the presence of magnesium ions, as supplied by Magnesium Chloride, is critical for the active conformation of kinases, facilitating ATP binding and the subsequent transfer of the phosphate group. The increase in kinase activity is a direct result of these ions stabilizing the active site and promoting enzyme-substrate interactions.
Other compounds exert their effects indirectly by modulating the balance of phosphorylation within the cell. For example, Sodium Orthovanadate acts as a phosphatase inhibitor, preventing the removal of phosphate groups that kinases attach. This creates a cellular environment with heightened phosphorylation, in which Lymphokine-activated killer T-cell-originated protein kinase may exhibit enhanced activity due to the overall increase in phosphorylated substrates and signaling molecules. Phosphatase inhibitors like Okadaic Acid and Calyculin A similarly raise the phosphorylation state within cells, supporting the sustained activity and signaling of kinases. However, based on the general role of kinases in cell signaling, we can infer that certain types of compounds that modulate kinase activity might influence this protein's activity.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Magnesium ions are essential cofactors for kinase enzymes, and their presence is required for ATP binding and phosphoryl transfer, thus enhancing kinase activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
As a phosphatase inhibitor, sodium orthovanadate can indirectly enhance kinase activity by preventing dephosphorylation of proteins, maintaining the phosphorylation state that kinases promote. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which can lead to the activation of protein kinase A (PKA) and potentially enhance downstream kinase activities. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to an increase in phosphorylation levels of various proteins, potentially enhancing the functional activity of kinases by reducing their dephosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a wide array of target proteins, potentially enhancing the activity of downstream kinases. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases, potentially influencing the activity of related kinases. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases, which may result in the augmented function of kinases due to reduced dephosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has been shown to inhibit certain protein kinases, but this action can indirectly enhance the activity of other kinases through compensatory mechanisms within the cell. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases, potentially influencing the activity of other kinases through stress response pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can result in altered activity of the AKT signaling pathway and may indirectly affect other kinases that are regulated by this pathway. | ||||||