PATJ Activators
PATJ activators are a category of chemicals that modulate the activity of the PALS1-associated tight junction protein, commonly known as PATJ. PATJ is an important scaffolding molecule that participates in the assembly and maintenance of tight junctions in epithelial and endothelial cells, which are crucial for the establishment and regulation of barriers controlling paracellular transport and cellular polarity.
Direct activators of PATJ may interact with the protein to bolster its role in the tight junction complex. This could involve enhancing its interaction with other tight junction components, such as PALS1 (protein associated with Lin7, Scribble cell polarity complex component), or with transmembrane proteins like claudins and occludins, which are integral to the function of tight junctions. Through direct interaction, these activators could stabilize PATJ within the complex, potentially leading to a more robust tight junction assembly and improved barrier function. Indirect activators of PATJ could operate by upregulating the expression of the PATJ gene, thus increasing the protein levels and enhancing the integrity of tight junctions. Alternatively, they may inhibit pathways that lead to the degradation or mislocalization of PATJ, ensuring that a greater proportion of the protein is correctly situated and active at the tight junction. Indirect activators could also influence the post-translational modifications of PATJ, such as phosphorylation, which may affect its binding properties or interaction with other cellular machinery involved in the maintenance of cell polarity and junctional integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Increased cAMP can activate Protein Kinase A (PKA), which then phosphorylates Tight Junction (TJ) proteins, including PATJ, modulating its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic receptor agonist leading to elevated cAMP levels. Higher cAMP levels can stimulate PKA, which in turn phosphorylates and activates PATJ. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits cAMP phosphodiesterase, leading to increased intracellular cAMP levels. Elevated cAMP levels can stimulate PKA, leading to phosphorylation and activation of PATJ. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is an adrenergic receptor agonist, which can increase cAMP levels. Increased cAMP levels can activate PKA, which then phosphorylates and activates PATJ. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine can stimulate beta-adrenergic receptors, leading to increased cAMP levels. Increased cAMP levels can subsequently activate PKA, which then phosphorylates and activates PATJ. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a beta-2-adrenergic receptor agonist, which can elevate cAMP levels. Elevated cAMP levels can stimulate PKA, leading to phosphorylation and activation of PATJ. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, causing an increase in intracellular cAMP levels. Elevated cAMP levels can stimulate PKA, which in turn phosphorylates and activates PATJ. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine interacts with several G-protein coupled receptors, influencing cAMP levels. This impact on cAMP levels can modulate PKA, leading to the phosphorylation and activation of PATJ. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine modulates various adenosine receptors, which can influence cAMP levels. This modulation can activate PKA, leading to the phosphorylation and activation of PATJ. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine interacts with G-protein coupled receptors, including H1 and H2, leading to changes in cAMP levels. This can stimulate PKA, leading to the phosphorylation and activation of PATJ. | ||||||