PAGE-2B Inhibitors
PAGE-2B inhibitors are a specialized class of chemical compounds that target and inhibit the protein known as PAGE-2B (Preferentially Expressed Antigen in Gastrointestinal Cancer 2B). PAGE-2B is a member of the PAGE family of proteins, which are known for their restricted expression patterns and roles in various cellular processes. These proteins are typically expressed in specific tissues and are involved in several biological functions, including gene regulation and cellular differentiation. PAGE-2B, in particular, has been identified in studies related to cancer and developmental biology due to its unique expression profile and potential involvement in cell signaling pathways.
Inhibitors of PAGE-2B are designed to selectively bind to the PAGE-2B protein or its associated molecular targets, thereby obstructing its activity. These inhibitors can come in various forms, including small molecules, peptides, or antibodies, each tailored to interfere with PAGE-2B's function in a specific manner. By inhibiting PAGE-2B, these compounds aim to alter the interactions and activities of PAGE-2B within cells. This class of inhibitors plays a critical role in research aimed at understanding the biological roles of PAGE-2B, as well as elucidating its involvement in cellular mechanisms and disease processes. The development and application of PAGE-2B inhibitors provide valuable tools for studying the functional significance of PAGE-2B in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that leads to the downregulation of HIF-1α under hypoxic conditions. As PAGE-2B expression is upregulated by HIF-1α, its inhibition through mTOR could decrease PAGE-2B activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor which prevents the activation of AKT, leading to reduced phosphorylation and activation of downstream targets. This inhibition could reduce the activity of PAGE-2B, which is potentially regulated by PI3K/AKT signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor that interferes with the MAPK/ERK pathway. By inhibiting MEK, the pathway is downregulated, which could result in decreased activation or expression of PAGE-2B if it is downstream of this signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Another MEK inhibitor that specifically inhibits the activation of MAPK/ERK, leading to reduced transcriptional activation of genes downstream of this pathway, potentially including PAGE-2B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A p38 MAPK inhibitor which prevents the activation of the p38 MAPK pathway. Inhibition of this pathway could affect the functional activity of PAGE-2B if it is involved in the p38 MAPK signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK which could lead to the inhibition of AP-1 transcription factor activity, thereby potentially decreasing the expression of PAGE-2B if it is a target of AP-1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent PI3K inhibitor which impairs AKT activation, leading to a decrease in the phosphorylation of downstream proteins that may include PAGE-2B or its regulators. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
An inhibitor of ROCK kinase which can interfere with actin cytoskeletal rearrangements. Since PAGE-2B could be involved in cell adhesion or motility, inhibition of ROCK may reduce PAGE-2B related functions. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
An FGFR inhibitor that can block the FGFR tyrosine kinase activity. This inhibition may affect the downstream signaling pathways that regulate PAGE-2B activity or expression. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor which could disrupt mitotic spindle formation. If PAGE-2B is involved in cell cycle regulation or mitosis, its function could be indirectly inhibited by such disruption. | ||||||