PADI1 Inhibitors
PADI1 inhibitors are a class of chemical compounds designed to specifically inhibit the activity of the enzyme Peptidylarginine Deiminase 1 (PADI1). PADI1 is one of the isoforms of the peptidylarginine deiminase family of enzymes, which are responsible for converting arginine residues in proteins into citrulline through a process known as citrullination or deimination. This post-translational modification can significantly alter the structure and function of proteins, affecting various cellular processes such as gene expression, protein interactions, and cellular signaling.
Inhibitors of PADI1 are typically small molecules that interact with the enzyme's active site, preventing it from binding to its substrate and carrying out the citrullination reaction. By blocking this enzymatic activity, PADI1 inhibitors can disrupt the normal physiological processes mediated by PADI1. Research into PADI1 inhibitors focuses on understanding the specific roles of PADI1 in various cellular contexts and how its inhibition affects the overall cellular landscape. These inhibitors serve as valuable tools for elucidating the function of citrullination in biological systems and investigating the broader implications of modulating PADI1 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may downregulate PADI1 expression by hindering the activation of nuclear factor-kappa B (NF-κB), a protein complex that plays a role in the transcription of PADI1. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate could reduce PADI1 expression indirectly by hindering the folate pathway, which is essential for the synthesis of nucleotides and the transcriptional processes of many genes. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid might lead to a decrease in PADI1 expression by suppressing inosine monophosphate dehydrogenase, which is crucial for purine synthesis and consequently for the replication and transcription of DNA. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could suppress PADI1 gene transcription by binding to retinoic acid receptors that, when activated, may repress the transcription of certain genes including PADI1. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine is likely to decrease PADI1 expression by inhibiting the NF-κB pathway, which could reduce the transcriptional activation of the PADI1 gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may decrease PADI1 expression by activating sirtuin 1 (SIRT1) and adenosine monophosphate-activated protein kinase (AMPK), which are known to play roles in cellular stress responses and could lead to the downregulation of PADI1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may reduce PADI1 expression as a consequence of its inhibition of the mammalian target of rapamycin (mTOR) pathway, which is involved in the control of protein synthesis and cell growth. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram could inhibit the activity of PADI1 by chelating copper ions, which are necessary cofactors for PADI1 activity, potentially causing a subsequent reduction in PADI1 expression. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine may decrease PADI1 expression through its immunomodulatory effects that alter cytokine production, which could subsequently lead to a reduction in the transcription of the PADI1 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could inhibit PADI1 expression by causing DNA hypomethylation at the PADI1 gene promoter site, which may result in a decrease in PADI1 transcription. | ||||||