PACS-1a Activators
Phosphofurin Acidic Cluster Sorting Protein 1, abbreviated as PACS-1, is a multifunctional protein that plays a crucial role in intracellular sorting and trafficking within eukaryotic cells. With a molecular weight of approximately 90 kDa, PACS-1 is distinguished by its ability to interact with various proteins, influencing their intracellular localization and function.PACS-1 is characterized by the presence of acidic cluster-dileucine signals in its structure. These signals are critical for its role in mediating the sorting of proteins to different cellular compartments, such as the trans-Golgi network (TGN) and endosomes. This sorting mechanism is essential for the proper distribution and functioning of proteins within the cell, impacting processes like signaling, metabolism, and membrane trafficking.
One of the key functions of PACS-1 is its involvement in the trafficking of the mannose-6-phosphate receptors (MPRs). MPRs are responsible for transporting lysosomal enzymes from the Golgi to lysosomes. PACS-1 assists in this process by binding to the MPRs and directing their transport to the appropriate cellular locations.Moreover, PACS-1 interacts with various other proteins, including the Furin convertase. This interaction is crucial for regulating the activity of Furin, a protein involved in the maturation of precursor proteins into their active forms. By controlling Furin's localization within the cell, PACS-1 indirectly influences numerous biological pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can indirectly affect PACS-1a by modulating cellular signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and potentially affecting PACS-1a activity indirectly. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which is involved in various signaling pathways that could intersect with PACS-1a regulated pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially impacting PACS-1a through calcium-dependent pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation, which may indirectly influence PACS-1a activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, which could indirectly affect PACS-1a's role in protein sorting. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, potentially influencing intracellular trafficking and indirectly impacting PACS-1a. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that alters intracellular pH and ion concentrations, which may affect PACS-1a related pathways. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine can alter cellular trafficking and endocytosis, potentially impacting PACS-1a functions. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Niclosamide disrupts multiple cellular processes including autophagy, which might indirectly affect PACS-1a activity. | ||||||