Date published: 2026-3-14

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p55 Inhibitors

p55 inhibitors are a class of chemical compounds that have garnered interest in the fields of molecular biology and modulate specific cellular processes. p55, also known as p55CDC, is a regulatory protein that plays a crucial role in cell division and the cell cycle. Specifically, it is associated with the regulation of the cell cycle at the G2/M transition, ensuring the proper progression of cells from the G2 phase to mitosis. p55 is involved in interactions with various cellular proteins, including cyclin-dependent kinases (CDKs) and checkpoint proteins, to coordinate cell cycle progression and maintain genomic stability. p55 inhibitors are designed to interact with the active site or binding domain of the p55 protein, effectively inhibiting its function and influencing cellular processes dependent on p55-mediated cell cycle regulation.

Structurally, p55 inhibitors are engineered to selectively target the active site or binding domains of p55, ensuring high specificity for this particular regulatory protein. By inhibiting p55, these compounds may disrupt its role in coordinating the G2/M transition of the cell cycle, leading to defects in cell division and genomic instability. The study of p55 inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions related to cell cycle control and DNA replication. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including cancer biology, cell proliferation disorders, and the molecular basis of diseases associated with abnormal cell cycle regulation. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of p55-mediated cell cycle regulation.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide has been shown to inhibit the transcription of various genes by affecting RNA polymerase II activity, which could lead to a reduction in MPP1 expression.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Actinomycin D intercalates into DNA and inhibits RNA polymerase, potentially decreasing MPP1 mRNA synthesis and expression.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Cycloheximide inhibits eukaryotic protein synthesis by interfering with ribosomal translocation, thus potentially reducing MPP1 protein levels.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Chloroquine can raise endosomal pH and potentially affect post-translational modification of proteins, which might influence MPP1 expression or localization.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG-132 inhibits proteasome activity, affecting protein turnover, which could alter MPP1 levels indirectly by modulating the degradation of proteins that regulate MPP1 expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid modulates gene expression through retinoic acid receptors and could theoretically affect the transcriptional regulation of MPP1.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

Mithramycin A binds to GC-rich sequences in DNA, inhibiting transcription factors and potentially reducing MPP1 gene expression.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine is incorporated into DNA and RNA, leading to DNA demethylation and alterations in gene expression, which might affect MPP1 levels.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Trichostatin A is a histone deacetylase inhibitor that can alter chromatin structure, potentially affecting the expression of genes including MPP1.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium butyrate acts as a histone deacetylase inhibitor that can affect gene expression patterns and potentially influence MPP1 transcription.