OTUD3 Activators
OTUD3 Activators represent a diverse set of chemical compounds that indirectly bolster the functional activity of OTUD3 via unique signaling pathways. Forskolin, by escalating cAMP concentrations, activates protein kinase A (PKA), which can phosphorylate proteins that interact with OTUD3, potentially enhancing its deubiquitinating function. Ionomycin similarly elevates intracellular calcium, which influences calcium-dependent proteases, possibly affecting OTUD3's activity. Additionally, Phorbol 12-myristate 13-acetate (PMA) stimulates protein kinase C (PKC), and Epigallocatechin gallate (EGCG) inhibits certain kinases, both leading to modifications in the phosphorylation patterns of proteins within OTUD3's interaction network, promoting its activity. Sphingosine-1-phosphate, through sphingolipid signaling, and Trichostatin A, by altering gene expression, may also affect the protein milieu surrounding OTUD3, consequently upregulating its functional capacity.
In parallel, Thapsigargin and A23187, both calcium ionophores, induce a rise in cytosolic calcium levels, potentially triggering calcium-dependent signaling cascades that interface with OTUD3's regulatory functions. LY294002, a PI3K inhibitor, and U0126, a MEK inhibitor, disrupt upstream signaling mechanisms, which might recalibrate cellular dynamics to favor OTUD3 activation. The p38 MAPK pathway, targeted by SB203580, and the broad kinase inhibition by Staurosporine, could similarly foster an environment conducive to OTUD3's enhanced activity by affecting the phosphorylation state of related proteins or by altering kinase-dependent regulation of OTUD3's substrates or associated factors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin serves as an activator of adenylate cyclase, thereby increasing levels of cAMP in the cell. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various targets that may interact with OTUD3, leading to its functional enhancement. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, potentially influencing calcium-dependent proteases that could modulate the activity of OTUD3 through altered proteolytic regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) which is involved in numerous signaling cascades. PKC-mediated phosphorylation can regulate the function of deubiquitinating enzymes like OTUD3, thus enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to inhibit certain types of kinases, which may relieve inhibitory phosphorylation on proteins that interact with OTUD3, thereby enhancing OTUD3 activity indirectly. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is involved in sphingolipid signaling and can activate signaling pathways that modulate proteostasis, potentially influencing the functional state of OTUD3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can alter chromatin structure and gene expression. This could lead to an increased expression of proteins that are substrates or regulators of OTUD3, enhancing its activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels which can activate calcium-dependent signaling pathways related to OTUD3 activity enhancement. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it can alter signaling pathways upstream of OTUD3, potentially leading to the enhancement of OTUD3's activity through changes in cellular signaling dynamics. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it can shift signaling balance in the cell, which can indirectly lead to the enhancement of OTUD3 activity through altered substrate availability or interaction. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. While it affects many kinases, it could selectively enhance OTUD3 activity by reducing competitive phosphorylation or by changing the activity of interacting proteins. | ||||||