OTTMUSG00000016607 Activators
KRAB box and zinc finger, C2H2 type domain containing, is a multifunctional protein involved in gene regulation, transcriptional control, and epigenetic modifications. It possesses a zinc finger domain that allows it to interact with specific DNA sequences and influence gene expression. This protein is known for its role as a transcriptional repressor, and its activation is essential for modulating the expression of various target genes. The activation of KRAB box and zinc finger protein primarily involves epigenetic mechanisms. Several chemicals, as listed in the table above, have been identified as activators of this protein. They function as histone deacetylase inhibitors, promoting histone hyperacetylation and ultimately leading to the epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. Additionally, some chemicals indirectly activate this protein by modulating specific signaling pathways that enhance its expression and functional activity.
In summary, the activation of KRAB box and zinc finger, C2H2 type domain containing, is crucial for its role in gene regulation and transcriptional control. The chemicals listed in the table provide valuable tools for researchers to study and manipulate the functions of this protein, particularly in the context of epigenetic modifications and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate activates the protein by functioning as a histone deacetylase inhibitor. It leads to histone hyperacetylation, resulting in the epigenetic activation of KRAB box and zinc finger protein. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid indirectly activates the target protein by modulating the retinoic acid receptor (RAR) signaling pathway, which enhances the expression and functional activation of KRAB box and zinc finger protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that activates the protein by promoting histone hyperacetylation, leading to the epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid activates the protein by inhibiting histone deacetylases (HDACs), resulting in increased histone acetylation and epigenetic activation of KRAB box and zinc finger protein. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin indirectly activates the target protein by modulating various signaling pathways, including NF-κB and AP-1, leading to increased expression and functional activation of KRAB box and zinc finger protein. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine activates the protein by incorporating into DNA and inhibiting DNA methyltransferases, resulting in DNA demethylation and subsequent expression and functional activation of KRAB box and zinc finger protein. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Aza-2'-deoxycytidine (Decitabine) activates the target protein by incorporating into DNA and inhibiting DNA methyltransferases, leading to DNA demethylation and functional activation of KRAB box and zinc finger protein. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide activates the protein by functioning as a histone deacetylase inhibitor. It promotes histone hyperacetylation, resulting in the epigenetic activation of KRAB box and zinc finger protein. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium Phenylbutyrate activates the protein by inhibiting histone deacetylases (HDACs), leading to increased histone acetylation and epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat (SAHA) is a histone deacetylase inhibitor that activates the protein by promoting histone hyperacetylation, leading to the epigenetic activation of KRAB box and zinc finger, C2H2 type domain containing. | ||||||