OTTMUSG00000016203 Activators
KRAB box and zinc finger C2H2 type domain containing protein isoform 2, abbreviated as Zfp966, is a key transcriptional regulator involved in various cellular processes. This protein contains zinc finger domains that enable it to bind to specific DNA sequences and modulate gene expression. Zfp966 plays a critical role in the regulation of gene transcription, thereby impacting diverse biological functions. Activation of Zfp966 can be achieved through both direct and indirect mechanisms. Direct activators like Forskolin, 8-Bromo-cAMP, Ionomycin, and Phorbol 12-myristate 13-acetate (PMA) act by directly stimulating Zfp966 or its downstream signaling pathways. For example, Forskolin activates Zfp966 by increasing intracellular cyclic AMP (cAMP) levels, which subsequently trigger protein activation.
Indirect activators like Retinoic acid, Trichostatin A, Sodium butyrate, and Dexamethasone modulate cellular pathways that indirectly influence Zfp966 activation. Retinoic acid, for instance, binds to retinoic acid receptors (RARs), leading to transcriptional regulation and increased expression of Zfp966. These activators collectively contribute to the regulation of Zfp966 activity, allowing it to function as a transcriptional regulator. Understanding the specific mechanisms of activation is essential in unraveling the intricate roles that Zfp966 plays in gene expression and cellular processes, contributing to our knowledge of its biological significance.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by binding to retinoic acid receptors (RARs), leading to transcriptional regulation and increased expression of the protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by inhibiting histone deacetylases (HDACs), leading to histone hyperacetylation and enhanced gene expression. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP directly activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 by mimicking cyclic AMP (cAMP), thereby stimulating downstream signaling pathways and protein activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by inhibiting HDACs, similar to Trichostatin A, resulting in enhanced gene expression and protein activation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin directly activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 by increasing intracellular calcium levels, which activate calcium/calmodulin-dependent kinases and stimulate the protein. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 directly by inhibiting protein tyrosine phosphatases (PTPs), resulting in increased phosphorylation and protein activation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by modulating the glucocorticoid receptor (GR) pathway, leading to increased gene expression and protein levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by inhibiting DNA methyltransferases, leading to demethylation of the protein's promoter region and increased gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) directly activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 by activating protein kinase C (PKC), which in turn phosphorylates the protein and enhances its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates KRAB box and zinc finger C2H2 type domain containing protein isoform 2 indirectly by modulating the Sirtuin 1 (SIRT1) pathway, which enhances deacetylation of histones and promotes gene expression, including the protein. | ||||||