OTTMUSG00000010009 Inhibitors
Chemical inhibitors of OTTMUSG00000010009 function by disrupting various signaling pathways that are crucial for the protein's activity. Rapamycin, a well-known inhibitor of the mTOR pathway, directly binds to and inhibits mTOR, a central regulator of cell growth and proliferation which is essential for the function of OTTMUSG00000010009. Similarly, Wortmannin and LY294002 focus on the PI3K/Akt/mTOR signaling pathway, with Wortmannin irreversibly inhibiting PI3K and LY294002 selectively targeting the same kinase, resulting in diminished phosphorylation and activation of downstream elements that are vital for OTTMUSG00000010009's role in the cell. PD98059 and U0126 both act as selective inhibitors of MEK1/2, thereby preventing the activation of the MAPK/ERK pathway, a pathway known to influence cell growth and survival, and consequently, the function of OTTMUSG00000010009. SB203580 and SP600125 each target specific MAP kinase pathways, with SB203580 inhibiting p38 MAP kinase and SP600125 inhibiting JNK, both of which are important for regulating cell cycle and stress response pathways that affect OTTMUSG00000010009 activity.
Continuing the inhibition profile, PP2 disrupts the signaling by Src family tyrosine kinases, which are involved in various cellular processes including cell adhesion, growth, and differentiation, thereby altering the signaling context in which OTTMUSG00000010009 operates. GF109203X targets protein kinase C (PKC), which is crucial for phosphorylation events that control cell cycle progression and apoptosis, hence affecting OTTMUSG00000010009 function. BAY 11-7082 inhibits the activation of NF-κB, a factor involved in regulating immune and inflammatory responses, thereby influencing the signaling environment pertinent to OTTMUSG00000010009. Lastly, LY3214996 provides a more targeted approach, specifically inhibiting ERK1/2 within the MAPK/ERK pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin forms a complex with FKBP12 and binds directly to mTOR, inhibiting its activity. Since mTOR is a central regulator of cell growth and proliferation, its inhibition by Rapamycin can lead to a functional inhibition of OTTMUSG00000010009 by hampering the protein synthesis machinery that would otherwise be active in an mTOR-dependent manner. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, a kinase involved in the Akt/mTOR signaling pathway. By blocking PI3K, Wortmannin can reduce the phosphorylation and activation of downstream targets, thus inhibiting the pathways that are necessary for the full functional activity of OTTMUSG00000010009. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a selective inhibitor of PI3Ks. By inhibiting PI3K, LY294002 can suppress the Akt signaling pathway, leading to a decrease in mTOR activity. This can indirectly inhibit OTTMUSG00000010009 by reducing the protein synthesis and other cellular processes that are modulated by the PI3K/Akt/mTOR pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of MEK1/2, which play a critical role in the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can prevent the phosphorylation and activation of ERK, potentially leading to an inhibition of OTTMUSG00000010009 by altering the signaling events that control cell growth and survival. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. Inhibition of p38 MAPK by SB203580 can lead to decreased activation of downstream targets involved in cell cycle regulation and stress responses. This can result in functional inhibition of OTTMUSG00000010009 by affecting the proper regulation of these cellular processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathway. By inhibiting JNK, SP600125 can impair the cellular responses to stress and cytokines, which could lead to an inhibition of OTTMUSG00000010009 through the alteration of signaling events that impact cell survival and proliferation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is another MEK1/2 inhibitor, which by blocking MEK, can inhibit the ERK pathway, a pathway that is implicated in the regulation of growth and survival. Inhibition by U0126 can lead to functional inhibition of OTTMUSG00000010009 by altering the cellular signaling involved in the protein's functional regulation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. By selectively inhibiting these kinases, PP2 can disrupt various signaling pathways, including those linked to cell adhesion, growth, and differentiation, which can lead to functional inhibition of OTTMUSG00000010009 by changing the signaling context of its activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X is a potent inhibitor of protein kinase C (PKC). By inhibiting PKC, GF109203X can affect the phosphorylation of downstream targets that regulate cell cycle progression and apoptosis, leading to functional inhibition of OTTMUSG00000010009 by affecting these regulatory mechanisms. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB activation. By inhibiting the IκB kinase complex, BAY 11-7082 can prevent the activation of NF-κB-dependent signaling. This inhibition can lead to the functional inhibition of OTTMUSG00000010009 by affecting the signaling pathways that regulate immune and inflammatory responses. | ||||||