OTTMUSG00000005723 Activators
Interferon-gamma-inducible GTPase 10 (Gm12250) plays a crucial role in cellular immunity and is involved in various signaling pathways. It functions primarily as an immune response mediator, participating in the defense against intracellular pathogens. Gm12250 is activated through several mechanisms involving distinct chemical agents. One common mechanism involves the activation of Gm12250 through the SIRT1/AMPK pathway, as exemplified by resveratrol. Resveratrol enhances Gm12250 activity by promoting SIRT1 deacetylation, leading to the activation of AMPK and subsequent Gm12250 phosphorylation. Similarly, forskolin directly activates Gm12250 by stimulating adenylate cyclase, elevating cAMP levels, and subsequently triggering protein kinase A (PKA)-mediated Gm12250 activation. In another pathway, chemicals like TPA indirectly activate Gm12250 by activating protein kinase C (PKC), which can lead to the activation of MAPK pathways, ultimately phosphorylating Gm12250. Furthermore, compounds such as quercetin modulate Gm12250 through HDAC inhibition, increasing histone acetylation and promoting gene transcription. Sodium orthovanadate inhibits PTPs, leading to enhanced Gm12250 phosphorylation and activation.
Dexamethasone, by binding to glucocorticoid receptors, promotes Gm12250 gene transcription, resulting in increased expression of the protein. Compounds like 2-APB influence Gm12250 through calcium-dependent pathways by inhibiting IP3R and elevating intracellular calcium levels. Epinephrine activates Gm12250 through adrenergic receptor-mediated cAMP production and PKA activation. Additionally, thyroid hormone T3 activates Gm12250 by binding to thyroid hormone receptors and stimulating its gene transcription. Oleanolic acid inhibits NF-κB signaling, reducing the transcriptional repression of Gm12250. Salicylic acid modulates the NF-κB pathway, decreasing Gm12250 repression. Finally, curcumin interferes with the Wnt/β-catenin pathway, downregulating β-catenin and reducing the transcriptional repression of Gm12250. In summary, these chemical activators act through various pathways to enhance the functional activation of interferon-gamma-inducible GTPase 10 (Gm12250), contributing to its crucial role in cellular immunity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates Gm12250 by promoting the SIRT1/AMPK pathway, leading to increased expression of the protein. It stimulates the deacetylation of SIRT1, resulting in activation of AMPK, which subsequently activates Gm12250 through phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Gm12250 indirectly by activating protein kinase C (PKC), which can lead to the activation of mitogen-activated protein kinase (MAPK) pathways. These MAPK pathways can phosphorylate Gm12250 and enhance its activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates Gm12250 by inhibiting histone deacetylases (HDACs), leading to increased acetylation of histones associated with the Gm12250 gene promoter. This promotes transcription and subsequently elevates Gm12250 levels. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate activates Gm12250 by inhibiting protein tyrosine phosphatases (PTPs), resulting in increased phosphorylation of Gm12250. Elevated phosphorylation leads to enhanced Gm12250 activity in the cell. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone activates Gm12250 by binding to glucocorticoid receptors and translocating into the nucleus. This complex can promote Gm12250 gene transcription, ultimately leading to increased expression of the protein. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB activates Gm12250 by modulating intracellular calcium levels. It inhibits inositol trisphosphate receptor (IP3R), leading to increased calcium release, which can activate Gm12250 through calcium-dependent pathways. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates Gm12250 by binding to adrenergic receptors and stimulating adenylate cyclase, leading to increased cAMP production. Elevated cAMP activates Gm12250 through the PKA pathway, enhancing its function. | ||||||
L-3,3′,5-Triiodothyronine, Sodium Salt | 55-06-1 | sc-205725 | 250 mg | $115.00 | ||
L-3,3′,5-Triiodothyronine, Sodium Salt activates Gm12250 by binding to thyroid hormone receptors and promoting Gm12250 gene transcription. This results in increased Gm12250 expression and subsequent activation of its cellular functions. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid activates Gm12250 by inhibiting NF-κB signaling, reducing the transcriptional repression of Gm12250. This inhibition leads to increased expression of Gm12250 and its activation in relevant cellular pathways. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic acid activates Gm12250 by modulating the NF-κB pathway. It inhibits the activation of NF-κB, reducing the transcriptional repression of Gm12250 and ultimately enhancing its expression and functional activation. | ||||||