OTRPC4 Activators
OTRPC4 activators encompass a diverse group of chemical compounds that enhance the protein's activity through various biochemical mechanisms. Forskolin and 1-Ethyl-2-benzimidazolinone, both elevate intracellular cAMP levels, thereby potentially enhancing OTRPC4 activity through cAMP-dependent protein kinase A (PKA). PKA activation leads to the phosphorylation of pertinent substrates, including OTRPC4, which can increase its channel activity. Similarly, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate OTRPC4 or its regulatory proteins, augmenting the channel's functionality. Ionomycin, by increasing intracellular calcium levels, could also enhance OTRPC4 activity through calcium-dependent phosphorylation mechanisms. Furthermore, the kinase inhibitor Epigallocatechin gallate (EGCG) might upregulate OTRPC4 activity by inhibiting kinases that exert a negative regulatorycontrol over the channel. BAY K 8644, by acting as an L-type calcium channel agonist, potentially increases calcium influx, leading to the indirect upregulation of OTRPC4 through calcium-dependent signaling pathways.
Anandamide enhances OTRPC4 activity through G-protein-mediated signaling pathways, adjusting the ion channel dynamics. Capsaicin, a known activator of certain TRP channels, may potentiate OTRPC4 by increasing intracellular calcium levels, which, in turn, could amplify OTRPC4 channel activity. Arachidonic acid could activate kinases that phosphorylate OTRPC4 or its associated regulatory proteins, thereby enhancing channel activity. Alternatively, Nitrendipine's antagonism of L-type calcium channels may invoke a compensatory cellular response, potentially leading to the upregulation of OTRPC4 as part of a broader homeostatic adjustment. The peptide toxin GsMTx-4, known for its inhibition of mechanosensitive channels, could indirectly magnify OTRPC4-mediated currents by reducing competition from these channels. Lastly, SKF-96365, a TRP channel blocker, may indirectly increase OTRPC4 activity by inhibiting competing TRP channels, thereby channeling the ionic currents towards OTRPC4-mediated transport. Collectively, these activators work through distinct but interconnected signaling pathways to enhance the functional activity of OTRPC4, culminating in a concerted modulation of the channel's physiological role.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels which can enhance OTRPC4 activity by activating PKA that may phosphorylate OTRPC4 or associated regulatory proteins, thus increasing OTRPC4 channel activity. | ||||||
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
This compound acts as a PDE inhibitor, increasing cAMP levels similarly to Forskolin and thereby potentially augmenting OTRPC4 function by means of PKA activation and subsequent phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate OTRPC4 or interact with signaling molecules related to OTRPC4 regulation, thus potentiating its channel activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular Ca²⁺ concentration, potentially enhancing OTRPC4 activity through Ca²⁺-dependent phosphorylation or allosteric effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can affect multiple pathways, potentially enhancing OTRPC4 activity by inhibiting kinases that negatively regulate the channel's activity. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K 8644 acts as an L-type calcium channel agonist which may increase Ca²⁺ influx, indirectly upregulating OTRPC4 activity through a calcium-dependent mechanism. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is known to activate certain TRP channels and could enhance OTRPC4 by promoting Ca²⁺ influx through these channels, leading to increased OTRPC4 activity due to elevated intracellular Ca²⁺. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid can activate certain protein kinases which could lead to the phosphorylation of OTRPC4 or its regulatory proteins, thereby enhancing the channel's activity. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine blocks L-type calcium channels leading to a compensatory cellular response that could upregulate OTRPC4 function as part of a homeostatic mechanism. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 is a TRP channel blocker that may increase OTRPC4 activity by inhibiting competing TRP channels, thus shifting cellular ionic currents to favor OTRPC4-mediated transport. | ||||||