Molecular structure of 1-EBIO, CAS Number: 10045-45-1
1-EBIO (CAS 10045-45-1)
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Alternate Names:
1-ethyl-1,3-dihydro-2h-benzimidazol-2-one
Application:
1-EBIO is a potassium channel modulator of epithelial KCa channels
CAS Number:
10045-45-1
Purity:
≥99%
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-EBIO is the first activator of epithelial KCa channels identified. 1-EBIO stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic valve endothelial cells. 1-EBIO is an activator of CFTR, SK and Ik1. 1-EBIO has also been used as a model substrate for studying the mechanisms of enzymatic catalysis in organic solvents.
1-EBIO (CAS 10045-45-1) References
- 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels. | Adeagbo, AS. 1999. Eur J Pharmacol. 379: 151-9. PMID: 10497901
- 1-EBIO stimulates Cl- secretion by activating a basolateral K+ channel in the mouse jejunum. | Hamilton, KL., et al. 1999. Pflugers Arch. 439: 158-66. PMID: 10651013
- Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels. | Syme, CA., et al. 2000. Am J Physiol Cell Physiol. 278: C570-81. PMID: 10712246
- Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells. | Gao, L., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 281: L1123-9. PMID: 11597903
- Activation of endothelial cell IK(Ca) with 1-ethyl-2-benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery. | Walker, SD., et al. 2001. Br J Pharmacol. 134: 1548-54. PMID: 11724762
- Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation. | Parihar, AS., et al. 2003. Eur J Pharmacol. 471: 157-64. PMID: 12826234
- Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). | Strøbaek, D., et al. 2004. Biochim Biophys Acta. 1665: 1-5. PMID: 15471565
- Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration. | Kusama, N., et al. 2005. Br J Pharmacol. 146: 487-97. PMID: 16056232
- In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant. | Anderson, NJ., et al. 2006. Eur J Pharmacol. 546: 48-53. PMID: 16925994
- SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. | Fay, AJ., et al. 2006. Proc Natl Acad Sci U S A. 103: 17548-53. PMID: 17085590
- The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients. | Roth, EK., et al. 2011. PLoS One. 6: e24445. PMID: 21909392
- Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel. | Devor, DC., et al. 1996. Am J Physiol. 271: L775-84. PMID: 8944721
- Modulation of Cl- secretion by benzimidazolones. II. Coordinate regulation of apical GCl and basolateral GK. | Devor, DC., et al. 1996. Am J Physiol. 271: L785-95. PMID: 8944722
Inhibitor of:
IRF-1, KVβ.2, and Slo3.Activator of:
Bestrophin-3, CFTR, CLC-KB, HERG, Ik1, KChIP1, KChIP2, KCNE1L, KCNE3, KCNH4, KCNH5, KCNQ5, KCTD16, KIR2.4, KIR2.6, KVβ.3, KV1.6, LRRC26, OTRPC4, SK, SK1, SK3, TALK-2, TWIK-2, and TWIK-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-EBIO, 10 mg | sc-201695 | 10 mg | $87.00 | |||
1-EBIO, 50 mg | sc-201695A | 50 mg | $325.00 |