OTRPC4 Inhibitors
Chemical inhibitors of OTRPC4 include a variety of compounds that can inhibit its function by interacting directly with the channel or its associated protein complexes. Ruthenium Red is one such inhibitor that can obstruct the ion channel pore of OTRPC4, thereby halting the influx of cations which are crucial for its function. Similarly, SKF-96365 can inhibit OTRPC4 by obstructing receptor-operated calcium channels, a category that encompasses TRPC family channels, ultimately reducing calcium entry into the cell which is essential for the protein's activity. The lanthanum ion, La3+, offers a different mode of inhibition by competing with calcium ions, which are pivotal for calcium permeation through OTRPC4. This competition blocks the channel and disrupts its function. Another compound, 2-APB, alters the gating mechanism of OTRPC4, which is a critical process for ion flow regulation through the channel.
In addition to these direct inhibitors, there are several compounds that inhibit OTRPC4 by targeting channels that can form heteromeric assemblies with it or are otherwise functionally related. Pyr3, for instance, binds to and inhibits TRPC3 channels that can assemble with OTRPC4, reducing the composite channel's activity. ML204 selectively targets TRPC4 channels, which share structural and functional characteristics with OTRPC4, while BTP2 focuses on inhibiting store-operated calcium entry, a crucial process for TRPC channel function, which includes OTRPC4. SAR7334 directly targets TRPC6 channels, which can interact functionally with OTRPC4 and modulate its activity. Furthermore, HC-070 and Pico145 inhibit OTRPC4 by blocking TRPC4 and TRPC5 channels, as well as TRPC1/4/5 channels respectively, which are closely related and potentially form heteromeric channels with OTRPC4. Lastly, AMG 9810 inhibits TRPV1 channels, which can influence the regulation of cellular signaling pathways that control OTRPC4 activity or may interact directly with OTRPC4.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red can inhibit OTRPC4 by blocking the ion channel pore, thereby preventing cation influx. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 inhibits OTRPC4 by blocking receptor-operated calcium channels, which include members of the TRPC family, thus reducing calcium entry into the cell. | ||||||
Lanthanum | 7439-91-0 | sc-250228 | 25 g | $180.00 | ||
La3+, a lanthanum ion, can inhibit OTRPC4 by competing with calcium ions and blocking calcium permeation through the channel. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB inhibits OTRPC4 by altering the channel gating mechanism and thus reducing the flow of ions through the channel. | ||||||
Pyr3 | 1160514-60-2 | sc-301624 sc-301624A sc-301624B | 5 mg 10 mg 25 mg | $148.00 $255.00 $510.00 | ||
Pyr3 inhibits OTRPC4 by specifically binding to and blocking TRPC3 channels, which may form heteromeric assemblies with OTRPC4, resulting in reduced activity of the latter. | ||||||
4-Methyl-2-(1-piperidinyl)-quinoline | 5465-86-1 | sc-483337 | 25 mg | $430.00 | ||
ML204 inhibits OTRPC4 by selectively targeting and blocking TRPC4 channels, which likely share structural and functional similarities with OTRPC4. | ||||||
SAR7334 | 1333210-07-3 | sc-507445 | 10 mg | $510.00 | ||
SAR7334 inhibits OTRPC4 by directly targeting and inhibiting TRPC6 channels, which can functionally interact with OTRPC4, resulting in the modulation of its activity. | ||||||
A-967079 | 1170613-55-4 | sc-363348 sc-363348A sc-363348B | 5 mg 25 mg 100 mg | $86.00 $365.00 $924.00 | 5 | |
A-967079 inhibits OTRPC4 by selectively blocking TRPA1 channels, which may be involved in complex formation or functional interaction with OTRPC4. | ||||||
AMG-9810 | 545395-94-6 | sc-201477 sc-201477A | 10 mg 50 mg | $84.00 $337.00 | 3 | |
AMG 9810 inhibits OTRPC4 by blocking TRPV1 channels, which may alter the cellular signaling pathways that regulate the activity of OTRPC4 or interact directly with OTRPC4 to modulate its function. | ||||||