OTOP1 Activators
OTOP1 Activators encompass a diverse array of chemical compounds that indirectly influence the functional activity of OTOP1, a proton-selective ion channel that plays a role in maintaining ion homeostasis and sensing extracellular pH. For instance, benzamil and amiloride, both selective blockers of ENaCs, indirectly contribute to the enhancement of OTOP1 activity by increasing intracellular sodium, which could alter the ionic environment conducive to OTOP1 function. Additionally, capsaicin's activation of TRPV1 channels and the subsequent neuronal depolarization may fine-tune the proton gradients, thereby potentially amplifying OTOP1's proton channel activity. Zinc sulfate, providing bioavailable zinc ions, could potentiate OTOP1 by modulating its gating mechanisms, while ruthenium red and gadolinium chloride, which inhibit calcium and mechanosensitive channels respectively, may create intracellular conditions that favor OTOP1 activation, particularly under acidic or mechanical stress-induced scenarios.
Furthermore, the biochemical landscape that OTOP1 operates within is intricately modulated by other activators like quinine and verapamil, which, by altering potassium and calcium channel activity, respectively, could shift the electrochemical gradient in a way that enhances proton flow through OTOP1. The chloride channel inhibitors baicalein and niflumic acid may also play a role in modulating OTOP1 activity by impacting the chloride-proton antiport system, leading to a favorable electrochemical potential for OTOP1 activity. Ethoxyzolamide's role in reducing hydrogen carbonate reabsorption hints at its potential to induce intracellular acidification, a state under which OTOP1 could be more active. Lastly, bafilomycin A1, by inhibiting the H+ ATPase pump, could effectively elevate the intracellular proton concentration, thus augmenting the gradient necessary for proton conduction through OTOP1. Collectively, these chemical agents, through their targeted modulation of cellular ion dynamics and membrane potentials, indirectly enhance the functional activity of OTOP1, contributing to its proton-selective conductance without the need for direct interaction with the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin binds to the transient receptor potential vanilloid 1 (TRPV1) channel, causing depolarization in sensory neurons. This depolarization could influence proton gradients and thus potentially enhance OTOP1 activity by modulating the electrochemical environment the protein operates in. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a known modulator of various ion channels and receptors. Zinc sulfate can increase the availability of zinc ions, which may potentiate the proton channel function of OTOP1 by stabilizing the channel structure or influencing its gating mechanisms. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride is an ENaC inhibitor similar to benzamil. It can also increase intracellular sodium concentration, which in turn can enhance OTOP1 activity as a result of altered sodium/proton exchange or membrane potential changes that affect proton flux through OTOP1. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is an inhibitor of certain calcium channels. By inhibiting extracellular calcium entry, it may cause intracellular acidification, which could provide a favorable condition for the activation of OTOP1, as it might be more active under acidic conditions. | ||||||
Gadolinium(III) chloride | 10138-52-0 | sc-224004 sc-224004A | 5 g 25 g | $150.00 $350.00 | 4 | |
Gadolinium ions block various ion channels, including stretch-activated ones. By modulating the activity of these channels, gadolinium chloride can alter the mechanical stress on cells, which may indirectly enhance OTOP1 activity if mechanical stretch influences its gating. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is a known blocker of certain potassium channels. By blocking these channels, quinine can alter the membrane potential, potentially enhancing the activity of OTOP1 by shifting the electrochemical gradient in a manner that favors proton flow through the channel. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that could lead to reduced calcium influx, potentially causing intracellular conditions that indirectly activate OTOP1 if the protein is sensitive to calcium-dependent signaling cascades or cellular pH changes. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein is known to inhibit certain chloride channels. By inhibiting these channels, it could affect the ionic balance across the membrane, which may indirectly enhance the activity of OTOP1, particularly if chloride ions influence the proton selectivity or gating of the channel. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is a known blocker of chloride channels. Similar to baicalein, by altering chloride flux, niflumic acid may affect the function of OTOP1, potentially enhancing its activity through changes in membrane potential or ionic gradients that affect proton conduction. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the H+ ATPase pump. By inhibiting this pump, it can increase intracellular proton concentration, which may indirectly enhance the proton-selective channel function of OTOP1 due to a higher proton gradient. | ||||||