Osteoadherin Inhibitors
Osteoadherin, also known as Osteoglycin, is a proteoglycan predominantly expressed in bone tissues and cartilage, where it exerts critical roles in modulating cell-matrix interactions and maintaining tissue homeostasis. Functionally, Osteoadherin serves as a key mediator of cellular processes such as cell adhesion, migration, and proliferation by interacting with various extracellular matrix components, including collagen and fibronectin. Through these interactions, Osteoadherin facilitates the attachment of cells to the extracellular matrix, thereby influencing tissue organization and structural integrity. Moreover, Osteoadherin has been implicated in regulating osteoblast differentiation and bone mineralization, highlighting its significance in skeletal development and remodeling processes.
Inhibition of Osteoadherin can be achieved through diverse mechanisms targeting different cellular pathways and processes. Proteasome inhibitors, for instance, prevent the degradation of proteins, potentially leading to the accumulation of Osteoadherin within cells. Additionally, inhibitors targeting histone acetyltransferases and heat shock protein 90 (Hsp90) may interfere with the transcriptional regulation and stability of Osteoadherin, respectively. Furthermore, inhibition of various kinases involved in signaling pathways such as MAPK/ERK, JNK, and p38 MAPK can disrupt Osteoadherin expression or function, impacting cellular processes mediated by this proteoglycan. Moreover, inhibition of phosphoinositide 3-kinases (PI3Ks) and mTOR signaling pathways may perturb the downstream signaling cascades implicated in Osteoadherin regulation, further contributing to its downregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. By inhibiting proteasomal activity, it leads to the accumulation and stabilization of proteins, potentially including Osteoadherin. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that blocks the proteolytic activity of the 26S proteasome. By preventing protein degradation, it may result in the accumulation and increased levels of Osteoadherin. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a selective inhibitor of the histone acetyltransferase p300/CBP. Inhibition of p300/CBP may affect gene transcription, potentially leading to downregulation of Osteoadherin expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin inhibits heat shock protein 90 (Hsp90), a molecular chaperone involved in protein folding and stability. Inhibition of Hsp90 may lead to degradation of Osteoadherin or interference with its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Inhibition of PI3Ks may disrupt signaling pathways involved in Osteoadherin regulation or cellular processes mediated by Osteoadherin. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1 and MEK2, upstream kinases in the MAPK/ERK signaling pathway. Inhibition of this pathway may affect Osteoadherin expression or function, leading to its downregulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinases (JNKs), key regulators of various cellular processes. Inhibition of JNKs may influence Osteoadherin expression or function, potentially leading to its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB202190 inhibits p38 MAPK, a signaling kinase involved in cellular responses to stress and inflammation. Inhibition of p38 MAPK may impact Osteoadherin expression or function, leading to its downregulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. Inhibition of mTOR signaling may affect Osteoadherin expression or function, potentially leading to its downregulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK1 and MEK2, upstream kinases in the MAPK/ERK signaling pathway. Inhibition of this pathway may influence Osteoadherin expression or function, leading to its downregulation. | ||||||