OSR2 Inhibitors
OSR2 inhibitors represent a class of chemical compounds specifically designed to target and modulate the activity of oxidative stress-responsive 1 (OSR1) and oxidative stress-responsive kinase 2 (OSR2). These kinases play crucial roles in cellular signaling pathways that regulate ion transport and maintain cellular homeostasis. OSR1 and OSR2 are members of the serine/threonine-protein kinase family and are implicated in various physiological processes, including the control of ion transport across cell membranes. One of the primary functions of OSR2 is its involvement in the regulation of ion channels, such as the WNK (with-no-lysine) family of serine-threonine kinases, which are key regulators of ion transport and blood pressure. OSR2 inhibitors act by interfering with the enzymatic activity of OSR2, thereby modulating downstream signaling pathways involved in ion transport.
The development of OSR2 inhibitors stems from the recognition of the essential roles played by OSR1 and OSR2 in cellular processes, particularly in maintaining ion balance. By selectively inhibiting the catalytic activity of OSR2, these compounds hold promise in unraveling the intricate signaling mechanisms associated with ion transport. The detailed understanding of the structural and biochemical aspects of OSR2 inhibition provides a foundation for the rational design of these compounds, allowing for the exploration of potential applications in various biological contexts.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Interferes with the Hedgehog signaling pathway, which may regulate the expression of various transcription factors including OSR2. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A PI3K inhibitor that might alter downstream signaling pathways affecting OSR2 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK1/2 which are upstream of ERK1/2 signaling, potentially altering OSR2-related transcriptional regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK, which can regulate cytoskeletal dynamics and might indirectly influence OSR2 function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits the TGF-β type I receptor ALK5, which may play a role in the regulation of transcription factors including OSR2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, potentially altering transcription factor activity and indirectly affecting OSR2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, which is involved in a wide range of cellular processes, possibly affecting OSR2 expression or function. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Inhibits Wnt production and could interfere with pathways that modulate OSR2 activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3β inhibitor that can modify Wnt/β-catenin signaling, potentially influencing OSR2. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
γ-secretase inhibitor that might impact Notch signaling, potentially affecting OSR2-related developmental processes. | ||||||