OSR2 Antibody (H-8): sc-393516
- OSR2 Antibody (H-8) is a mouse monoclonal IgG1 κ OSR2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 81-120 mapping within an internal region of OSR2 of human origin
- OSR2 Antibody (H-8) is recommended for detection of OSR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- Anti-OSR2 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-393516 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OSR2 Antibody (H-8) for WB applications. These reagents are now offered in bundles with OSR2 Antibody (H-8) (see ordering information below).
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OSR2 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects OSR2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OSR2 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OSR2 protein, which is 312 amino acids long and contains five zinc finger domains, plays a crucial role in embryonic development and bone formation, making OSR2 essential for proper skeletal development. OSR2 is predominantly expressed in the kidneys, skeletal muscle, testis, and mouse embryos, where OSR2 is believed to influence transcriptional activity and osteoblast function. Notably, OSR2 is involved in regulating palatal development and the expression of alkaline phosphatase, with OSR2 expression being modulated by C/EBP regulatory elements. OSR2 exists in two isoforms, OSR2A and OSR2B, produced through alternative splicing; OSR2B is shorter by 36 amino acids and contains only three zinc finger motifs. Both isoforms localize to the nucleus and have opposing transcriptional activities, highlighting the complexity of OSR2′s regulatory functions. Mutations in the gene encoding OSR2 can disrupt the expression of critical genes such as Pax-9 and TGFβ3, further underscoring OSR2′s importance in developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OSR2 Antibody (H-8) References:
- Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. | Lan, Y., et al. 2001. Mech Dev. 107: 175-9. PMID: 11520675
- Human homologues of Osr1 and Osr2 are not involved in a syndrome with distal limb deficiencies, oral abnormalities, and renal defects. | Debeer, P., et al. 2002. Am J Med Genet. 111: 455-6. PMID: 12210313
- Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. | Lan, Y., et al. 2004. Development. 131: 3207-16. PMID: 15175245
- Odd-skipped related 2 splicing variants show opposite transcriptional activity. | Kawai, S., et al. 2005. Biochem Biophys Res Commun. 328: 306-11. PMID: 15670784
- Odd-skipped related 2 gene transcription is regulated by CCAAT enhancer-binding protein delta in mesenchymal C3H10T1/2 cells. | Kawai, S., et al. 2006. Genes Cells. 11: 163-75. PMID: 16436053
- Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. | Stricker, S., et al. 2006. Gene Expr Patterns. 6: 826-34. PMID: 16554187
- Odd-skipped genes encode repressors that control kidney development. | Tena, JJ., et al. 2007. Dev Biol. 301: 518-31. PMID: 17011543
- Zinc-finger transcription factor odd-skipped related 2 is one of the regulators in osteoblast proliferation and bone formation. | Kawai, S., et al. 2007. J Bone Miner Res. 22: 1362-72. PMID: 17547533
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSR2 Antibody (H-8) | sc-393516 | 200 µg/ml | $322.00 | |||
OSR2 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-530477 | 200 µg Ab; 10 µg BP | $361.00 | |||
OSR2 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-523975 | 200 µg Ab, 40 µg BP | $361.00 | |||
OSR2 Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-544073 | 200 µg Ab; 20 µg BP | $361.00 | |||
OSR2 Antibody (H-8) X | sc-393516 X | 200 µg/0.1 ml | $322.00 | |||
OSR2 Antibody (H-8) AC | sc-393516 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OSR2 Antibody (H-8) HRP | sc-393516 HRP | 200 µg/ml | $322.00 | |||
OSR2 Antibody (H-8) FITC | sc-393516 FITC | 200 µg/ml | $336.00 | |||
OSR2 Antibody (H-8) PE | sc-393516 PE | 200 µg/ml | $349.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 488 | sc-393516 AF488 | 200 µg/ml | $364.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 546 | sc-393516 AF546 | 200 µg/ml | $364.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 594 | sc-393516 AF594 | 200 µg/ml | $364.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 647 | sc-393516 AF647 | 200 µg/ml | $364.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 680 | sc-393516 AF680 | 200 µg/ml | $364.00 | |||
OSR2 Antibody (H-8) Alexa Fluor® 790 | sc-393516 AF790 | 200 µg/ml | $364.00 |