ORP-11 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $199.00 $599.00 | 24 | |
GW4869 is an inhibitor of neutral sphingomyelinase (nSMase), an enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Since ORP-11 is involved in the transport of cholesterol and potentially interacts with ceramide-rich domains, inhibiting nSMase with GW4869 decreases ceramide levels, which could disrupt membrane microenvironments essential for ORP-11 function, leading to its functional inhibition. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $106.00 | 8 | |
Myriocin is a potent inhibitor of serine palmitoyltransferase, the initial step in sphingolipid synthesis. By reducing sphingolipid synthesis, myriocin can alter lipid rafts where ORP-11 may localize and function, thereby inhibiting ORP-11's role in intracellular lipid transport. | ||||||
D609 | 83373-60-8 | sc-201403 sc-201403A | 5 mg 25 mg | $185.00 $564.00 | 7 | |
D609 is an inhibitor of phosphatidylcholine-specific phospholipase C, which is involved in the generation of diacylglycerol, a molecule that can interact with ORP-11. Inhibition with D609 can disrupt lipid signaling pathways and membrane dynamics, potentially inhibiting the function of ORP-11 in lipid exchange and transport. | ||||||
Fumonisin B1 | 116355-83-0 | sc-201395 sc-201395A | 1 mg 5 mg | $117.00 $469.00 | 18 | |
Fumonisin B1 is an inhibitor of ceramide synthase, leading to a decrease in complex sphingolipid levels. Since ORP-11 is implicated in lipid trafficking and may interact with sphingolipids, the reduction of sphingolipid levels by Fumonisin B1 could inhibit ORP-11's functional interactions with these lipids. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
U18666A is a cholesterol transport inhibitor that can induce intracellular cholesterol accumulation and disrupt cholesterol homeostasis. As ORP-11 is involved in cholesterol transport, the action of U18666A can inhibit the proper localization and function of ORP-11 by perturbing cholesterol distribution. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $184.00 | ||
Perhexiline inhibits carnitine palmitoyltransferase-1 (CPT1), which is crucial for mitochondrial fatty acid uptake. By disrupting fatty acid metabolism, perhexiline could impair the lipid-related signaling and transport processes in which ORP-11 participates, leading to its functional inhibition. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
Guggulsterone is known to antagonize the farnesoid X receptor (FXR), which regulates bile acid and cholesterol homeostasis. By antagonizing FXR, guggulsterone can alter cholesterol trafficking pathways, potentially inhibiting ORP-11's function in these pathways. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $116.00 $145.00 | 26 | |
Filipin is a sterol-binding agent that disrupts cholesterol-rich domains within cellular membranes. ORP-11, being involved in cholesterol transport, may require interaction with these domains, and their disruption by filipin could inhibit ORP-11's functional activity. | ||||||
Cerulenin (synthetic) | 17397-89-6 | sc-200827 sc-200827A sc-200827B | 5 mg 10 mg 50 mg | $158.00 $306.00 $1186.00 | 9 | |
Cerulenin is an inhibitor of fatty acid synthase, which may disrupt lipid composition and metabolism. Changes in cellular lipid profiles can influence the transport and exchange functions of ORP-11, leading to its functional inhibition. | ||||||