OR5B12 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is a diuretic inhibiting sodium channels in kidney epithelial cells. By decreasing sodium reabsorption, it indirectly affects the olfactory signaling pathways where OR5B12 is involved, potentially leading to decreased sensitivity and activity of OR5B12 due to altered ion concentrations. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a TRPV1 receptor agonist, leading to calcium influx in sensory neurons. The resulting desensitization and potential depletion of intracellular signaling molecules can inhibit olfactory receptors like OR5B12 by altering the receptor's cellular environment. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
Iodoacetamide alkylates cysteine residues, affecting protein function. By modifying cysteine residues critical for OR5B12 function, it can inhibit the receptor's activity through covalent modification of its structure. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red is an inhibitor of calcium channels. By inhibiting calcium influx, it may decrease the activity of G-protein coupled receptors (GPCRs) like OR5B12, which rely on calcium signaling for their downstream effects. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $51.00 $131.00 | ||
Lidocaine is a local anesthetic that blocks sodium channels. Its use can lead to a decrease in neuronal excitability, potentially reducing the functional activity of GPCRs like OR5B12 in the olfactory system. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is a known bitter compound that can influence taste receptors and may have cross-activity with olfactory receptors. By binding to OR5B12, it could inhibit the receptor's natural agonists from binding and activating the receptor. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can modulate the activity of GPCRs. Zinc sulfate, providing zinc ions, can inhibit OR5B12 by altering its conformation or the receptor's local cellular environment, which is necessary for its proper function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions can also interfere with receptor function. Copper sulfate can inhibit olfactory receptors like OR5B12 by binding to them or altering their membrane environment, affecting their activity. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole is known to bind to and modify the function of copper-containing enzymes. By altering copper homeostasis, methimazole can indirectly inhibit OR5B12's function, which may require copper for proper signaling. | ||||||
Chloroform | 67-66-3 | sc-239527A sc-239527 | 1 L 4 L | $112.00 $204.00 | 1 | |
Chloroform's anesthetic properties can affect membrane fluidity and protein function. This could lead to the inhibition of membrane-bound receptors like OR5B12 by altering the receptor's environment and its ability to interact with ligands. | ||||||