OR51B6 Inhibitors
OR51B6 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the OR51B6 protein, which is part of the olfactory receptor (OR) family. Olfactory receptors are G-protein-coupled receptors (GPCRs) that play a significant role in detecting odorant molecules and initiating signal transduction pathways that lead to the perception of smell. OR51B6, like other olfactory receptors, is expressed not only in the nasal epithelium but also in various tissues, suggesting additional roles beyond olfaction, such as in cellular signaling and tissue-specific functions. By inhibiting OR51B6, researchers can study the specific contributions of this receptor to the olfactory system, as well as its potential involvement in non-olfactory signaling pathways.
Inhibitors of OR51B6 work by binding to the receptor's active site or modulating its interaction with ligands, thereby preventing the receptor from activating downstream signaling pathways. These inhibitors are useful for dissecting the functional roles of OR51B6, helping researchers to understand how its inhibition affects cellular communication and sensory processing. Additionally, OR51B6 inhibitors are employed to explore how olfactory receptors, including OR51B6, may influence physiological processes outside of smell perception, such as in tissue development or metabolic regulation. By blocking OR51B6 activity, scientists can uncover the receptor's broader functions and its potential involvement in complex cellular networks, thus offering insights into the intricate roles of olfactory receptors in both olfactory and non-olfactory systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, could potentially downregulate OR51B6 expression by altering chromatin accessibility and transcription factor binding to the gene's promoter region. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could decrease methylation levels of the OR51B6 gene promoter, potentially leading to its transcriptional downregulation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound intercalates into DNA, rendering it inaccessible to RNA polymerase and thus could decrease OR51B6 transcription by blocking elongation of its mRNA transcripts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which could lead to a reduction in protein synthesis capacity overall, including the synthesis of OR51B6, by initiating a general protein synthesis downregulation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine disrupts lysosomal acidification, which could inhibit the post-translational processing of OR51B6 and decrease its presentation on the cell surface. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP, which could initiate a signaling cascade leading to the downregulation of OR51B6 expression by altering transcription factor activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could decrease OR51B6 expression by binding to retinoic acid receptors which may repress the transcription of genes not aligned with retinoid signaling objectives. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could downregulate OR51B6 by inhibiting NF-κB signaling, potentially reducing the transcriptional activation of genes under NF-κB control, including olfactory receptors. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may decrease OR51B6 expression through activation of SIRT1, leading to deacetylation of histones or transcription factors involved in OR51B6 gene expression. | ||||||
Lithium Chloride | 7447-41-8 | sc-203110 sc-203110A sc-203110B sc-203110C sc-203110D sc-203110E | 50 g 250 g 1 kg 2.5 kg 5 kg 10 kg | $32.00 $62.00 $173.00 $347.00 $614.00 $1163.00 | 8 | |
Lithium chloride could inhibit GSK-3β signaling, leading to alterations in the Wnt pathway that may result in the transcriptional downregulation of OR51B6. | ||||||